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ALA Protocol

    

If I could only take ONE supplement (AFTER Vitamins C and D) it would probably be ALA   Make sure to take this Nutrient with Fat between meals

    

“Alpha Lipoic Acid is the standard of care therapy for neuropathy in Europe. In fact, in Germany, it's malpractice NOT to prescribe Alpha Lipoic Acid for a patient with neuropathy.”   Emergency Room Physician

“Alpha-lipoic acid is an essential cofactor in the production of energy and acts as a potent antioxidant. Alpha-lipoic acid has been shown to cause cell death in some tumor cell lines (15). In human studies, alpha-lipoic acid has been shown to improve insulin sensitivity in patients with type-2 diabetes mellitus (7). The roles of alpha-lipoic acid in reversing neuropathies (9) (11) and liver disease (10) have been studied. A meta-analysis of clinical trials of alpha-lipoic acid in diabetic patients showed a significant reduction in neuropathic symptoms (13). Topical application of creams containing alpha-lipoic acid may help prevent photo ageing of facial skin (14).”     Memorial Sloan-Kettering Cancer Center

“There is now widespread appreciation that atherosclerosis is a chronic inflammatory disease in which monocytes interact with activated endothelium. Our data provide new evidence that alpha-lipoic acid, due to its metal chelating and, possibly, antioxidant functions, inhibits endothelial activation both in cultured human cells and in mice, thus potentially delaying atherosclerosis and CVD. Elucidating the precise mechanisms by which alpha-lipoic acid disrupts endothelial adhesion molecule expression will be important in identifying other agents that may be specific and effective in inhibiting the initiation and progression of atherosclerosis and other inflammatory diseases.” Weijian Zhang, MD PhD, Note the adhesion molecule is signaling your immune system of infection within the artery wall, usually this infection is the deliberate Atherosclerosis your body is using to protect your arteries from bleeding out

“Because alpha-lipoic acid also is a good metal chelator, we hypothesized that metals may be involved in the production of adhesion molecules. To test this hypothesis, we added compounds to the cell culture that specifically chelate iron or copper. Our results showed that treatment with metal chelators also inhibits the production of adhesion molecules and monocyte adherence to cultured endothelial cells, thus supporting our hypothesis that the metal-chelating activity of alpha-lipoic acid may be responsible for its salubrious effects on endothelial cell function.” Weijian Zhang, MD PhD, Note we do know oxides of both iron and copper contribute to endothelial oxidation

“Although LA is a potent antioxidant in the test tube, LA supplementation may affect health by stimulating glutathione synthesis, enhancing insulin signaling and modulating the activity of other cell signaling molecules and transcription factors.” LPI ALA Biological Activity

“DHLA is a potent reducing agent with the capacity to reduce the oxidized forms of several important antioxidants, including vitamin C and glutathione (20). DHLA may also reduce the oxidized form of alpha-tocopherol (the alpha-tocopheroxyl radical) directly or indirectly, by reducing the oxidized form of vitamin C (dehydroascorbate), which is able to reduce the alpha-tocopheroxyl radical (21). Coenzyme Q10 is an important component of the mitochondrial electron transport chain that also has antioxidant activity. DHLA can also reduce oxidized forms of coenzyme Q10 (22), which may also reduce the alpha-tocopheroxyl radical (23).”    LPI ALA Biological Activity

ALA treated diabetic rats saw their blood glucose levels drop 23% - 43%.” Hypertension

ALA reduced the formation of glycosylated end products (AGEs).” Jain et al, Note ALA is one of the few ways  to combat glycation

“These results suggest Acetyl-L-Carnitine and ALA given to old rats improves performance in memory tasks by lowering oxidative damage and improving mitochondrial function.” Liu et al

“ALA appears to have a positive effect for cadmium toxicity, providing a protective effect for cadmium induced cell dysfunction and membrane damage in liver cells.” Muller et al

“I recommend taking supplemental biotin when supplemental ALA exceeds 100 mg/day.” Doctor Lester Packer

“Alpha-lipoic acid is a naturally occurring compound that appears to be useful in treating pathologies associated with oxidative stress. For example, alpha-lipoic acid has been safely used for more than 30 years in Europe to prevent and treat complications associated with diabetes, such as protein glycation, abnormal glucose utilization, polyneuropathy, and cataracts. Alpha-lipoic acid can also bind to, or chelate, metals like iron and copper. Exogenously supplied lipoic acid is readily absorbed by cells and tissues and then rapidly reduced to its potent antioxidant form, dihydrolipoate. We found that alpha-lipoic acid significantly inhibits both the formation of adhesion molecules and the adherence of monocytes to endothelial cells in culture.” Weijian Zhang, MD PhD

“Many of the B vitamins assist in the maximizing of the Krebs’s cycle, but none is as efficient as ALA.” Challem et al

ALA improved the detoxification capacity of cells by increasing glutathione levels and reducing lipid peroxidation.” Gurer et al

"Study shows alpha lipoic acid can lower triglycerides. Alpha-lipoic acid's mechanisms include inhibition of specific gene expression in the liver, lowering liver triglyceride secretion, and stimulating the clearance of triglyceride-rich lipoproteins. When the animals' livers were examined at the study's conclusion, those from rats treated with lipoic acid showed elevated glycogen levels, which suggests that more consumed carbohydrates were being stored as glycogen rather than becoming triglycerides. The extent of triglyceride reduction was really dramatic, we didn't expect it to be this profound. The potential is good that this could become another way to lower blood triglycerides and help reduce the risk of atherosclerosis. It's pretty exciting"   Archives of Biochemistry and Biophysics, Note this is huge and just what you want

"ALA directly increases ATP production in the mitochondria. Studies in aging animals support the use of R-ALA to improve mitochondrial function, decrease oxidative damage and increase metabolic rate, all of which become impaired with age."   Life Extension

"ALA has been comprehensively studied world wide for it's power to prevent or mitigate drug-induced kidney damage. ALA lowers protein loss in urine and improves kidney structure and function in diabetes laboratory animals by reducing oxidative stress."   Life Extension, Note this also holds for liver damage

"Lipoic acid and carnitine are small-molecule nutrients vital to your body's management of its energy flow. Potent antioxidants they are both credited with protecting mitochondria and thereby slowing the aging process. Exciting work is now emerging that shows that each of these nutrients in each of several forms, exerts its favorable anti-aging effects by chelating iron as well."   Life Extension

"ALA chelates mercury. ... Among other metals that ALA and its metabolite DHLA can chelate are copper, excess iron, cadmium, excess calcium, zinc and lead. ... we are just beginning to  understand the significance of ALA as a therapeutic agent for heavy metal poisoning."   Doctor Burt  Berkson, MD, PhD

"ALA has been comprehensively studied world wide for it's power to prevent or mitigate drug-induced kidney damage. ALA lowers protein loss in urine and improves kidney structure and function in diabetes laboratory animals by reducing oxidative stress."   Life Extension, Note this also holds for liver damage

10 Ways To Control Blood Sugar Without Medication

         

If I could only take ONE supplement (AFTER Vitamins C and D) it would probably be ALA

“Because alpha-lipoic acid also is a good metal chelator, we hypothesized that metals may be involved in the production of adhesion molecules. To test this hypothesis, we added compounds to the cell culture that specifically chelate iron or copper. Our results showed that treatment with metal chelators also inhibits the production of adhesion molecules and monocyte adherence to cultured endothelial cells, thus supporting our hypothesis that the metal-chelating activity of alpha-lipoic acid may be responsible for its salubrious effects on endothelial cell function.” Weijian Zhang, MD PhD, Note we do know oxides of both iron and copper contribute to endothelial oxidation

“There is now widespread appreciation that atherosclerosis is a chronic inflammatory disease in which monocytes interact with activated endothelium. Our data provide new evidence that alpha-lipoic acid, due to its metal chelating and, possibly, antioxidant functions, inhibits endothelial activation both in cultured human cells and in mice, thus potentially delaying atherosclerosis and CVD. Elucidating the precise mechanisms by which alpha-lipoic acid disrupts endothelial adhesion molecule expression will be important in identifying other agents that may be specific and effective in inhibiting the initiation and progression of atherosclerosis and other inflammatory diseases.” Weijian Zhang, MD PhD, Note the adhesion molecule is signaling your immune system of infection within the artery wall, usually this infection is the deliberate Atherosclerosis your body is using to protect your arteries from bleeding out

"Pharmaceutical companies are focusing massive resources to develop a drug that targets mitochondrial dysfunction,1 one of the major causes of the chronic diseases of aging.2 Much of their efforts are aimed at developing a patentable version of a natural compound called lipoic acid.3,4 For almost two decades, scientists have known that lipoic acid offers an effective solution to mitochondrial dysfunction.5 Ongoing clinical trials across the globe show the promise of lipoic acid’s benefits on a wide range of diseases—from diabetes to cardiovascular disease to Alzheimer’s and countless more.6 Fortunately, you don’t need to wait for Big Pharma to develop a synthetic, costly version of lipoic acid in order to combat mitochondrial dysfunction."   How Lipoic Acid Preserves Critical Mitochondrial Function

"Studies have revealed lipoic acid aids in preserving youthful cellular energy because of its ability to support the function of your cells’ power plants — mitochondria.15 The “R” form of lipoic acid is responsible for significantly supporting a healthy inflammatory response, and it is a potent free radical scavenger. The “R” form also has been shown to be more potent in some circumstances than the combined “R” and “S” forms that most supplements offer."   Uncovering the Not-So-Secret Secrets of Longevity and Overall Wellness

"Lipoic acid comes in two “mirror image” forms labeled “R” and “S.” The R form is the main form that is produced and used by life processes.7 Inexpensive chemical manufacturing produces equal quantities of R and S lipoic acid, often labeled “R/S Lipoic Acid” or simply “alpha lipoic acid” (ALA). Newer precision techniques allow production of a pure R-lipoic acid, which provides a much more concentrated potency. A dose of pure R-lipoic acid provides twice the active ingredient as a typical R/S-alpha lipoic acid supplement, simply because the whole dose consists of the active “R” molecule.7 Look for the “R” label to assure you are getting the most potent form of this valuable nutrient.104,105 "   How Lipoic Acid Preserves Critical Mitochondrial Function

    

Your body produces Alpha Lipoic Acid, sometimes also referred to as Lipoic Acid, but production falls off as we age. This superb antioxidant  and anti-mycotoxin (See Mycotoxin Protocol) recycles other antioxidants, may slow aging, repairs liver damage, chelates heavy metals and reduces your risk of cancer, heart disease and diabetes and much more.  ALA is regarded as a universal antioxidant.

As the above paragraphs show ALA plays a critical role in preventing CVD. IMO what is happening is free copper and free iron metabolites are often required to oxidize LDL packets and ALA mops up these key contributors to CVD.

  

ALA, Vitamin C, Vitamin ESelenium et al Can Recycle Other Antioxidants

"The chemical reactions by which oxidation occurs or is reversed are collectively called "redox" reactions.  Anti-oxidants have been found to work together in networks in chains of these reactions.  Research examining the reaction chains repeatedly document interactions between Vitamin C (as ascorbic acid) and Vitamin E (usually as alpha tocopherol) wherein Vitamin C donates an electron to a charged version of Vitamin E, thereby bringing Vitamin E back to a stable, "recycled" state.  Vitamin C then undergoes a "recycling" process of its own to revert to a stable state."   Does Vitamin C help "recycle" Vitamin E? If so, what is the process?

"The goal of this project is to define the interactions of selenium and vitamins C and E in preventing oxidant damage. Vitamin C recycles and thus preserves vitamin E or alpha-tocopherol in cell membranes. We showed that the selenoenzyme thioredoxin reductase, which is present in both cytosol and mitochondria, recycles vitamin C from both its oxidized forms. We hypothesize that thioredoxin reductase and vitamin C spare vitamin E in part through these mechanisms, and that vitamin C and other selenoenzymes also directly consume radicals that would otherwise oxidize vitamin E. "   Antioxidant Interaction of Selenium and Vitamins C &E

"It has now been shown that a vital selenocysteine-containing enzyme called thioredoxin reductase actively recycles exhausted CoQ10 (ubiquinone) molecules and turns them into active, oxidative stress-fighting ubiquinol molecules. In other words, selenium improves the efficacy of CoQ10."   Combining CoQ10 and Selenium Reduces Cardiovascular Mortality

"Diabetic stressors in the body are also largely influenced by the availability of other antioxidants. Both ALA and its reduced form, dihydrolipoic acid, not only act as antioxidants but they also stimulate the regeneration of other powerful free radical scavengers. Increases in the production of vitamin C, vitamin E, glutathione and several enzymes which exhibit antioxidant like behavior have all been found in association with the availability of ALA in the body (1, 2, 4). Researchers find that these antioxidants are consistently depleted when the body is suffering. When antioxidant levels are low or diminished, oxidative stress can wreak havoc on cellular pathways and all organs in the body. Although the mechanism by which ALA supports the production of other antioxidants is not yet fully understood, it is possible that ALA provides the thiol compound or sulfur that some proteins are missing in order to fulfill their duties and provide protection (10)."   Alpha Lipoic Acid: Key Benefits on Inflammation and Blood Sugar

"One of the main reasons why selenium deficiency is so damaging to heart muscle is because of the role selenium plays in protecting the heart against free radical damage, a leading risk factor for heart disease.81-83 Selenium is essential to the proper functioning of one of the heart’s most extensively studied protective mechanisms against oxidative stress—an enzyme called glutathione peroxidase.84 This enzyme is 100% dependent on having a selenium atom at its core for proper function.85 In fact, selenium is what gives the enzyme its potency in preventing and cleaning up after destructive oxygen free radicals."   How To Obtain Optimal Benefits From Selenium

"Selenium acts as a co-factor for several key antioxidant enzymes called selenoproteins that recycle cellular antioxidants such as glutathione.4 This process reduces oxidative stress, a cause of premature aging and chronic disease.1,2,5,6 Large-scale epidemiologic studies have repeatedly demonstrated that populations with low selenium levels are at significantly increased risk for developing many different types of cancer.1,2,7 These studies confirm that adequate dietary selenium exerts preventive effects on prostate and colorectal cancer, two of the most common types of malignancies.8-10"   Selenium Insufficiency Increases Cancer Risk

"I am very optimistic about the potential of dietary selenium as a broad-spectrum chemoprotectant against various viral diseases. A lot of that may be entirely due to the immune-stimulating and antioxidant benefits of selenium, but I think that in a number of viral diseases, some degree of direct interaction between the virus and selenium is likely to be involved. We already have quite a few viral diseases where a clinical correlation or definite selenium benefit has been established: hepatitis B/liver disease, HIV/AIDS, Coxsackie virus/Keshan disease, hemorrhagic fever, MMTV/cancer, and a number of other animal viral diseases where selenium has been used in veterinary practice. I also strongly suspect that various herpes viruses will prove responsive to selenium therapy, and the strongest case of a selenoprotein in a virus to date is in a pox virus. So the potential scope of this chemoprotection approach is very exciting."   Doctor Will Taylor PhD, University of Georgia

"CoQ10 reduces the oxidative stress, minimizes the damage to fragile mitochondria, and helps generate new mitochondria.18-20 All of this adds up to a more “fuel-efficient” body that is better equipped to carry out its necessary functions. This is especially important for the heart, which requires a tremendous amount of energy in order to function properly.  ... Selenium may better our bodies’ ability to produce and accumulate CoQ10.4 Studies show that animals deficient in selenium make only about 67% of the amount of CoQ10 that animals with sufficient selenium generate, and they also have trouble accumulating the CoQ10 that they do make.23 It has now been shown that a vital selenocysteine-containing enzyme called thioredoxin reductase actively recycles exhausted CoQ10 (ubiquinone) molecules and turns them into active, oxidative stress-fighting ubiquinol molecules. In other words, selenium improves the efficacy of CoQ10."   Combining CoQ10 and Selenium Reduces Cardiovascular Mortality

Here we see how ALA, Vitamin C, Vitamin ESelenium et al can recycle each other and other antioxidants, The simple point is IF you assure good amounts of each you may be providing the maximum anti-oxidant protection for your body.

      

ALA a KEY Antioxidant Recycling Player

"Several factors make ALA the ultimate antioxidant. One very basic reason is that ALA is both a hydrophilic and lipophilic molecule. Because it is hydrophilic,  it is soluble in blood and other watery body fluids. Because it is lipophilic it is also soluble in fats, ... ALA prevents free radical damage in every setting regardless of whether it is in the brain fluids; the blood, stored fats, the heart, the pancreas, the kidneys, bone, cartilage, the liver and for that matter every cell in every organ."   Doctor Burt  Berkson, MD, PhD

"Another very important property of ALA is its ability to salvage and recycle other antioxidants such as Vitamin C, Vitamin E and Glutathione. When any of these antioxidants do their jobs and are used up, ALA can make them serviceable again. Because of these characteristics ALA is very active in every cell and in the spaces between the cells."   Doctor Burt  Berkson, MD, PhD

“DHLA is a potent reducing agent with the capacity to reduce the oxidized forms of several important antioxidants, including vitamin C and glutathione (20). DHLA may also reduce the oxidized form of alpha-tocopherol (the alpha-tocopheroxyl radical) directly or indirectly, by reducing the oxidized form of vitamin C (dehydroascorbate), which is able to reduce the alpha-tocopheroxyl radical (21). Coenzyme Q10 is an important component of the mitochondrial electron transport chain that also has antioxidant activity. DHLA can also reduce oxidized forms of coenzyme Q10 (22), which may also reduce the alpha-tocopheroxyl radical (23).”    LPI ALA Biological Activity

"It is, in fact, DHLA that regenerates vitamin C and indirectly recycles vitamin E. Biochemists call this process antioxidant recycling. DHLA does its job and is transformed back into alpha lipoic acid, and then ALA can do its job again."   Doctor Burt  Berkson, MD, PhD

Above and Below we show how these antioxidants help recharge and recycle each other. This should prompt  you to assure you have more than sufficient amounts of each.

http://www.reikihm.com/images/Antioxidants.jpg

Here we see some of the interactions between ALA and other KEY antioxidant players.   

     

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ALA, Vitamin C et al Can Recycle Vitamin E and other Antioxidants

"The chemical reactions by which oxidation occurs or is reversed are collectively called "redox" reactions.  Anti-oxidants have been found to work together in networks in chains of these reactions.  Research examining the reaction chains repeatedly document interactions between Vitamin C (as ascorbic acid) and Vitamin E (usually as alpha tocopherol) wherein Vitamin C donates an electron to a charged version of Vitamin E, thereby bringing Vitamin E back to a stable, "recycled" state.  Vitamin C then undergoes a "recycling" process of its own to revert to a stable state."   Does Vitamin C help "recycle" Vitamin E? If so, what is the process?

"It is, in fact, DHLA that regenerates vitamin C and indirectly recycles vitamin E. Biochemists call this process antioxidant recycling. DHLA does its job and is transformed back into alpha lipoic acid, and then ALA can do its job again."   Doctor Burt  Berkson, MD, PhD

"As a powerful antioxidant, Coenzyme Q10 can increase absorption of other essential nutrients. It’s been shown that it helps recycle vitamin C and vitamin E, further maximizing the effects of vitamins and antioxidants that are already at work in the body."   All About CoQ10 Benefits, Foods, Supplements & More

After these anti-oxidants, ALA, and Vitamin C have done their anti-oxidant jobs they becomes reduced. YOU can recycle these back into the anti-oxidant form by having sufficient BOTH  ALA and Vitamin C to do this job. This increases the anti-oxidant work these anti-oxidants in your body can do.

http://www.vrp.com/static/editorialImages/lipoic.fig.1.jpg    

After these anti-oxidants, vitamin C, Vitamin E and ALA, have done their anti-oxidant jobs they becomes reduced. YOU can recycle these back into the anti-oxidant form by having sufficient BOTH VitaminC, Vitamin E and ALA to do this job. This increases the anti-oxidant work these anti-oxidants in your body can do.

   

Vitamin E Recycles ALA; Assure your Vitamin E

"Both vitamin E and coenzyme Q possess distinct lipoprotective antioxidant properties in biological membranes. Their combined antioxidant activity, however, is markedly synergistic when both are present together. While it is likely that vitamin E represents the initial chain-breaking antioxidant during lipid peroxidation, both fully reduced CoQH. (ubiquinol) and semireduced CoQH2 (ubisemiquinone) appear to efficiently recycle the resultant vitamin E phenoxyl radical back to its biologically active reduced form."    Coenzyme Q and vitamin E need each other as antioxidants

"Normally, when an antioxidant molecule accepts a free electron from an oxygen radical, it too becomes inactive. But vitamin E enjoys a special relationship with two other antioxidants, vitamin C and alpha lipoic acid, that allow it to continue protecting the skin.5 Both vitamin C and alpha lipoic acid have the ability to take away the extra electron from a used vitamin E molecule, effectively reactivating it.6 This capacity to recycle and restore its power makes vitamin E a prominent factor in the skin's first line of defense against free radicals."   Skin Protection Effects Of Vitamin E

After these anti-oxidants, Vitamin E and ALA, have done their anti-oxidant jobs they becomes reduced. YOU can recycle these back into the anti-oxidant form by having sufficient BOTH Vitamin E and ALA to do this job. This increases the anti-oxidant work these anti-oxidants in your body can do.

http://www.vrp.com/static/editorialImages/lipoic.fig.1.jpg

After these anti-oxidants, Vitamin E and ALA, have done their anti-oxidant jobs they becomes reduced. YOU can recycle these back into the anti-oxidant form by having sufficient BOTH Vitamin E and ALA to do this job. This increases the anti-oxidant work these anti-oxidants in your body can do.

   

Glutathione, ALA and Antioxidant Recycling

"The indispensible antioxidant glutathione is synthesized within the mitochondrion. Glutathione is a compound composed of the three amino acids; cysteine, glutamic acid and glycine. Since glutathione does not usually perform well when taken orally, what can be done to increase endogenous glutathione levels? Several scientists have demonstrated that ALA and its metabolite DHLA provoke the cell to produce significantly higher levels of glutathione."    Doctor Burt  Berkson, MD, PhD

"Glutathione is critical for one simple reason: It recycles antioxidants. You see, dealing with free radicals is like handing off a hot potato. They get passed around from vitamin C to vitamin E to lipoic acid and then finally to glutathione which cools off the free radicals and recycles other antioxidants. After this happens, the body can “reduce” or regenerate another protective glutathione molecule and we are back in business. However, problems occur when we are overwhelmed with too much oxidative stress or too many toxins. Then the glutathione becomes depleted and we can no longer protect ourselves against free radicals, infections, or cancer and we can’t get rid of toxins. This leads to further sickness and soon we are in the downward spiral of chronic illness."   Doctor Mark Hyman’s 9 Tips to Optimize your Glutathione Levels

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ALA improved the detoxification capacity of cells by increasing glutathione levels and reducing lipid peroxidation.” Gurer et al

Since Glutathione recycles many antioxidants and ALA helps to increase glutathione getting more ALA in your system is a no brainer.

   

Foods to Help Produce ALA

THIOLFOODSInfoGraphic

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ALA Benefits

“Alpha-lipoic acid is a naturally occurring compound that appears to be useful in treating pathologies associated with oxidative stress. For example, alpha-lipoic acid has been safely used for more than 30 years in Europe to prevent and treat complications associated with diabetes, such as protein glycation, abnormal glucose utilization, polyneuropathy, and cataracts. Alpha-lipoic acid can also bind to, or chelate, metals like iron and copper. Exogenously supplied lipoic acid is readily absorbed by cells and tissues and then rapidly reduced to its potent antioxidant form, dihydrolipoate. We found that alpha-lipoic acid significantly inhibits both the formation of adhesion molecules and the adherence of monocytes to endothelial cells in culture.” Weijian Zhang, MD PhD

"Recent data highlight the role of lipoic acid to counteract aging by improving mitochondrial function and decreasing oxidative stress. Owing to these properties, lipoic acid can protect against the destructive consequences of diabetes, obesity, heart disease, neurodegeneration, and cancer. Lipoic acid is so universally effective that pharmaceutical companies have modified lipoic acid to render it patentable and profitable. Fortunately, the natural form of lipoic acid is available without a prescription and for reasonable expense.7 Given its extensive health benefits, lipoic acid is an indispensable asset in one’s arsenal to combat aging."    How Lipoic Acid Preserves Critical Mitochondrial Function

  • Anti-Liver Disease
  • Anti-Diabetes
  • Anti-Atherosclerosis
  • Anti-Inflammation
  • Anti-CVD
  • Pro-Detoxification
  • Pro-Eye Health
  • Pro-Kidney
  • Pro-Krebs’s cycle
  • Pro-Endothelial
  • Pro-Liver
  • Modulates Blood glucose levels
  • Can Improve Memory
  • Can lower triglycerides
  • Can Reduce AGEs
  • Neutralizes Free Radicals
  • Recharges other Antioxidants, vitamins C,  D and E, CoQ10 and  glutathione
  • Chelates free metals including excess iron
  • Chelates Heavy Metals
  • Increases Glutathione
  • Active in both and oxidative and reduced state
  • Promotes Endothelial Health
  • Promotes Insulin effectiveness
  • Promotes cell Signaling
  • Promotes positive DNA transcription
  • Essential cofactor in the production of energy
  • Enzyme Cofactor
  • Both water and fat soluble has access to your entire body
  • Beneficial in MANY Diseases

    

ALA a supplement Workhorse

“Alpha-lipoic acid is an essential cofactor in the production of energy and acts as a potent antioxidant. Alpha-lipoic acid has been shown to cause cell death in some tumor cell lines (15). In human studies, alpha-lipoic acid has been shown to improve insulin sensitivity in patients with type-2 diabetes mellitus (7). The roles of alpha-lipoic acid in reversing neuropathies (9) (11) and liver disease (10) have been studied. A meta-analysis of clinical trials of alpha-lipoic acid in diabetic patients showed a significant reduction in neuropathic symptoms (13). Topical application of creams containing alpha-lipoic acid may help prevent photoageing of facial skin (14).”     Memorial Sloan-Kettering Cancer Center

ALA is soluble both in water and fat (See Fat Soluble Nutrients Protocol) so it operates both within and external to the cells as well as in the cell membrane. In addition ALA crosses the blood/brain barrier (See Blood Brain Protection Protocol) and thus has access to your Brain  and central nervous system. ALA recycles co-enzyme (See Enzymes Protocol) Q-10, vitamins C and E and most importantly it recycles glutathione. ALA increases insulin sensitivity. Most antioxidants once they quench a Free Radical by donating an electron can do no more useful work UNTIL they get another electron. ALA in rare counter distinction DOES do useful work, perhaps it's most important work, in this reduced state.  ALA chelates heavy metals such as mercury, lead, and arsenic, and it stabilizes NF kappa B transcription factor so that it helps to inactivate deleterious genes. It can also help people with diabetes by increasing the sensitivity of their cells to insulin, and it helps reverse diabetic neuropathies.

    

How and when to supplement ALA

“Because alpha-lipoic acid also is a good metal chelator, we hypothesized that metals may be involved in the production of adhesion molecules. To test this hypothesis, we added compounds to the cell culture that specifically chelate iron or copper. Our results showed that treatment with metal chelators also inhibits the production of adhesion molecules and monocyte adherence to cultured endothelial cells, thus supporting our hypothesis that the metal-chelating activity of alpha-lipoic acid may be responsible for its salubrious effects on endothelial cell function.” Weijian Zhang, MD PhD, Note we do know oxides of both iron and copper contribute to endothelial oxidation

If I could only take ONE Supplement (AFTER Vitamins C and D) it would probably be ALA. IMO everyone over 40 needs to take ALA. I take 300mg or more most everyday. Since taking ALA with a meal decreases its bioavailability, it is generally recommended that ALA be taken on an empty stomach (one hour before or two hours after eating). Since ALA is both fat and water-soluble take a little fat with it to help with its absorption.  600 mg of ALA/day for four months has been found to significantly reduce oxidative stress in healthy people. I often take a course of 300 or more mg/day for a few weeks.

    

The Forms of ALA

"Lipoic acid comes in two “mirror image” forms labeled “R” and “S.” The R form is the main form that is produced and used by life processes.7 Inexpensive chemical manufacturing produces equal quantities of R and S lipoic acid, often labeled “R/S Lipoic Acid” or simply “alpha lipoic acid” (ALA). Newer precision techniques allow production of a pure R-lipoic acid, which provides a much more concentrated potency. A dose of pure R-lipoic acid provides twice the active ingredient as a typical R/S-alpha lipoic acid supplement, simply because the whole dose consists of the active “R” molecule.7 Look for the “R” label to assure you are getting the most potent form of this valuable nutrient.104,105 "   How Lipoic Acid Preserves Critical Mitochondrial Function

"Studies have revealed lipoic acid aids in preserving youthful cellular energy because of its ability to support the function of your cells’ power plants — mitochondria.15 The “R” form of lipoic acid is responsible for significantly supporting a healthy inflammatory response, and it is a potent free radical scavenger. The “R” form also has been shown to be more potent in some circumstances than the combined “R” and “S” forms that most supplements offer."   Uncovering the Not-So-Secret Secrets of Longevity and Overall Wellness

 

Most ALA supplements consist of a fifty-fifty mix of the synthetic ALA isomer S-ALA with the natural R-ALA. The R-ALA is the most active in your body. You can buy the all-natural R-ALA but it’s more expensive. The S-ALA should produce R-ALA once it has gone through the oxidation-reduction cycle.

The reduced form of ALA, R-DHLA has been used in recent studies suggesting that R-DHLA may help prevent mitochondrial decay, diabetes, Alzheimer’s disease, atherosclerosis, and other disorders associated with aging. ALA will prevent many problems but it appears only R-DHLA will repair them.  ALA itself should produce R-DHLA as it is reduced.

If you have a serious degenerative condition find out about the R-DHLA form of ALA and/or the R-ALA form. I continue to use ALA. If you take supplemental ALA you should take supplemental biotin (See Biotin Protocol) at a different time as the two compete for the same absorption resources. Be sure to take a vitamin B complex (See Vitamin B Complex Protocol) supplement if you take biotin.

Get the book “The Alpha Lipoic Acid Breakthrough”  by Burt Berkson to learn more about this wonderful tool for your good health.

   

Possible Risks With ALA Supplementation

"Side effects were observed in patients when the ALA supplement dose exceeded 2,000 mg/day. These side effects included skin reactions, loss of appetite and hypoglycemia or the condition of low blood sugar. Following dosage adjustments, 1,200 mg/day of ALA supplementation was preferred for optimal glycemic control with zero notable risks associated. (1). Another study found that when ALA is consumed as a dietary supplement, unintended cardiovascular risks were seen in patients who do not undergo exercise training (8 ). When exercise was utilized in combination with ALA supplements to control glucose, there were no adverse health effects on cholesterol or blood pressure. These possible risks associated with ALA supplementation in diabetics beg the questions: Which is worse? Loss of site, kidney and nerve function or working up a sweat while listening to your favor tunes?"   Alpha lipoic acid

   

Conclusion

If I could only take ONE supplement (AFTER Vitamins C and D) it would probably be ALA. I have been taking 300 –  500 mg/ most days of ALA for many decades.

The Role of Lipoic Acid in Inflammation and Atherosclerosis

    

More on ALA

http://www.lef.org/magazine/mag2005/feb2005_report_lipoic_01.htm

http://www.townsendletter.com/Dec2007/alphalipo1207.htm

http://www.ralapure.com/

http://www.berkeley.edu/news/media/releases/96legacy/releases.96/14316.html

http://lpi.oregonstate.edu/infocenter/othernuts/la/

 

 

 

This File was last updated on 26 February 2019 02:57 PM

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