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DNA Damage/Repair Protocol

    

Learn what damages and what repairs your DNA and ACT on IT

     

"When you are young, you have less DNA damage, so the DNA repair mechanisms are less active. As you get older, you have more DNA damage and less capacity to fix it, so that category becomes extraordinarily important."   Dr. Sandra Kaufmann The Science of Slowing Aging

"On a daily basis, our DNA is under attack from numerous sources, including radiation, oxidative stress, environmental hazards, and dietary carcinogens. The extent to which DNA damage occurs—or can be prevented—correlates closely with how long we will live. One course of action is to protect ourselves with compounds that can prevent DNA damage before it leads to cancer. ... Xanthohumol, a compound found in hops, has now been shown in human and animal studies to significantly reduce DNA damage induced both by natural chemical stresses, as well as by some notorious dietary carcinogens. In addition, chlorophyllin and watercress have been shown to reduce DNA damage via several mechanisms. Fortunately, science has identified powerful nutrients that protect against DNA damage and its consequences"   Protect against DNA damage

“NAC has been found to be an effective preventive and treatment for a variety of conditions involving glutathione depletion. There is overwhelming evidence that NAC has the ability to modulate a variety of DNA damage and cancer related end points.” De Flora et al, 2001  

"Ultraviolet (UV) light produces DNA damage that plays an important role in causing a variety of diseases. When scientists exposed cells in culture first to UV light and then to blueberry extracts, they found both a reduction in reactive oxygen species and reduced DNA damage.42 Closer examination showed that cells were protected even after DNA damage had occurred, the mechanism being related to decreased genetic expression of stress-induced signaling proteins. This study showed that blueberry anthocyanins protect DNA from damage and protect cells from the consequences of DNA damage that did occur."    Blueberries Boost Longevity Beyond Calorie Restriction

"Additionally, blueberries have been shown to fight DNA damage, metabolic syndrome, heart disease, and even cancer. Rich in anthocyanins and pterostilbenes, blueberries are becoming a critical component of a science-based longevity program."   Blueberries Increase Life Span Across Species

“These results suggest carotenoids may inhibit tumor initiation, which is compatible with hypothesized mechanisms, including the conversion of provitamin A carotenoids to retinol, which regulates cell growth, differentiation, and apoptosis, and the antioxidant capacity to scavenge reactive oxygen species and prevent DNA damage,” stated authors Heather Eliassen of Harvard University and colleagues."   Life Extension   Note This study is worth heeding IMO. Carotene provides ALL the very important Vitamin A family of nutrients. Here is the evidence that this can lower the risk for and provide treatment for Breast Cancer.

The other major area of cocoa health research has been in the food's ability to fight cancer. Studies suggest that cocoa polyphenols can inhibit the growth of cancer cells, prevent DNA damage that causes cancer, and even inactivate certain carcinogenic chemicals.”    How dark chocolate really is the 'food of the gods': fights inflammation, cancer, Alzheimer's and more

“We have to figure out why our patients did not get well. Sometimes it can be something as crazy as they lived close to a cell phone tower. We got the patient to move, she did not die and is doing great.”   Doctor Nicholas Gonzales MD, Cancer Specialist, Note here it is folks right from the horses mouth, One likely damage mechanism is the DNA damage from Genotoxic Effects – RFR and ELF DNA Damage

"Studies show that higher coffee consumption decreases levels of oxidative DNA damage which in turn inhibits both cancer and aging."   Life Extension

"Indole-3-carbinol (I3C) is found in anti-cancer vegetables such as cabbage, cauliflower, and broccoli. When I3C is given to rodents before they are treated with cancer-causing chemicals (carcinogens), the number of tumors can be reduced by 96%. I3C has been shown to extend the length of the time between exposure to carcinogens and development of tumors by nearly 200%.178 One of the ways I3C protects cells against cancerous changes is by preventing DNA damage. I3C protects DNA not only in breast tissue, but in other tissues as well. A study from the Medical College of Ohio shows that I3C can cut the rate of DNA damage from chemicals in breast tissue by almost 92%.179 Others have shown that I3C decreases DNA damage in white blood cells by 82%, colon by 67%, and liver by 69%.179 This would seem almost unbelievable if it hadn't been confirmed by others who have shown that I3C can reduce DMBA-induced liver DNA damage by 90%, lung and trachea by 55%, and other tissues by similar amounts.180"   Are You Cooking Yourself to Death

“NAC has been found to be an effective preventive and treatment for a variety of conditions involving glutathione depletion. There is overwhelming evidence that NAC has the ability to modulate a variety of DNA damage and cancer related end points.” De Flora et al, 2001  

"The researchers studied toxicity mechanisms of four different Roundup formulations in human cells. The formulations were diluted at minimal doses (up to 100,000 times or more), but they still caused cell death within a few hours. The researchers also noted membrane and DNA damages, and found the formulations inhibit cell respiration." Chemical Research in Toxicology January 2009;22(1):97-105, Note here is the coming cancer epidemic

“Nonlinear resonance, however, is capable of such damage and this sheds light on the genotoxic effects inherent in the utilization of THz waves upon living tissue. The team emphasizes in their abstract that the effects are probabilistic rather than deterministic. Unfortunately, DNA damage is not limited only to THz wave exposure. Other research has been done that reveals lower frequency microwaves used by cell phones and Wi-Fi cause some harm to DNA over time as well.”    Single- and double-strand DNA breaks in rat brain cells after acute exposure to radiofrequency electromagnetic radiation.

"Green tea protects against many age-accelerating factors, particularly DNA damage, while also promoting DNA repair. These systems work with extreme precision to identify, remove, and heal damaged DNA.3,4 A recent analysis showed that green tea polyphenols have 200 human target genes, including those involved in inflammation, cancer, diabetes, neurodegenerative, muscular, and cardiovascular disease.5 In addition, green tea supplementation has been found to significantly reduce the risk of diabetes, stroke, and depression and improve blood levels of cholesterol and glucose.6 "   Green Tea

"In a study 9 men received zinc depleted diets for 42 days. DNA strand breaks increased by an average of 57% by the end of the period, indicating that six weeks of reduced zinc intake significantly increases DNA damage in peripheral blood cells. These increases proved reversible by restoring adequate zinc."   Linus Pauling Institute

“Obviously, melatonin’s ability to protect DNA from oxidative damage has implications for many types of cancer, including leukemia, considering that DNA damage due to free radicals is believed to be the initial oncostatic event in a majority of human cancers.”  Cerutti et al., 1994

"Much of NACs beneficial activity derives from it's capacity to modulate expression of genes for myriad signaling molecules in the inflammatory response. NACs ability to replenish the intercellular glutathione supply and mitigate oxidative damage affords protection against DNA damage and cancer development. NAC inhibits cytokine production credited with cancer reduction."    Life Extension

"Ginseng is another plant important in traditional medicine that confers substantive radioprotective effects.82,83 A variety of ginseng extracts have been shown to protect against radiation-induced DNA damage.84-86 It protects hair follicles and other rapidly reproducing (but healthy) tissues from damage by radiation.87,88 Its antioxidant effects have resulted in protection of a variety of radiation-sensitive tissues, including cells in bone marrow, spleen, and testicles.82,89 Ginseng’s immunomodulatory effects make it especially useful in defending our bodies against the ravages of radiation injury.90 A North American ginseng extract was recently found to protect human white blood cells from DNA damage even up to 90 minutes following radiation exposure.91”   Life Extension

"One mechanism involved in cancer development is oxidative stress and the DNA damage that it causes. Selenium is a natural element capable of fighting oxidative stress and has been shown to be effective in preventing cancer and the biochemical changes that precede it."   Selenium and Cancer Prevention   Note WOW!

"Lemon balm can boost levels of the superoxide dismutase (SOD), an essential component of the body’s native ability to protect itself from the effects of ionizing radiation and other major chemical stresses.19  Lemon balm defends lipid cell membranes in living organisms, as shown by a sharp reduction in the lipid peroxidation that is a measure of direct cell damage following radiation exposure.19 Lemon balm also protects DNA, as shown by a reduction in the amount of the plasma marker 8-OH-dG, a product of oxidized DNA damage.19,21 "   Cancer Risks Of CT Scans

"Chlorella, a unicellular green algae that has the highest chlorophyll content of any known organism. Chlorella has been shown to protect against DNA damage and telomere shortening due to free radicals,26 to boost the immune system,27 and to protect against environmental dioxin toxins.28."   Takekoshi H, et al

“Curcumin, derived from the curry spice turmeric, exerts powerful radioprotective effects as a result of its antioxidant and detoxifying characteristics.64 Curcumin supplements reduce DNA damage and tumor formation in rats; they reduce both DNA damage and lipid peroxidation in cultured human white blood cells.65,66 Curcumin has “dual action.” Its antioxidant effects protect normal tissue from radiation. But it also upregulates genes responsible for cell death in cancers, enhancing tumor destruction by radiation.67 The result is increased survival in animals exposed to high-dose radiation.68”   Life Extension

"Sirtuin activators that are hundreds of times more powerful than resveratrol increase insulin sensitivity, and have therefore been proposed as a treatment for type II diabetes.21 Powerful sirtuin-activators have also been shown to improve the general health and lifespan of mice fed a normal diet.22 Sirtuins can rejuvenate cells by stimulating the recycling of damaged cellular components (autophagy). Sirtuins require the substance NAD+ to function. Sirtuins are important for DNA repair and for efficient function of the energy-producing cellular organelles, mitochondria."   Sirtuins and NAD+ for Rejuvenation

"Resveratrol supplied sirtuins can stabilize chromosomes and DNA molecules, preventing breaks and damage that can lead to cancer, they promote DNA repair and they regulate genetic functions that in turn control every activity in the living cell." Life Extension

"Aging consists of seven categories of things that happen to your cells. No. 1: Changes to DNA, including epigenetic modification and telomere length. No. 2: Disruptions in energy production due to mitochondria failure. No. 3: Problems with metabolic pathways, especially the sirtuins, AMPK, and mTOR pathways. No 4: Quality control problems that affect DNA and protein repair. No. 5: Inflammatory issues due to a faulty immune system. No. 6: Not fulfilling the needs of specific cells. No. 7: Incomplete waste management. To defeat aging, or decelerate the process, you have to take into consideration each of the seven categories."   Dr. Sandra Kaufmann The Science of Slowing Aging

"So how do you protect DNA? The best agents I’ve found are sulforaphanes, which you find in broccoli and other cruciferous vegetables; the medicinal plant astragalus; and the diabetes drug metformin."   Dr. Sandra Kaufmann The Science of Slowing Aging

Preventing and Repairing DNA Damage is a health task we must be constantly aware of. This is not that difficult to do. MANY of the above nutrients that have been shown to Prevent and/or Repair DNA Damage are nutrients we need to take for MANY Other reasons. Just note the ones you are already taking and connect them with their salubrious DNA effects; consider taking others for their DNA effects.

     

Old Age and DNA

"When you are young, you have less DNA damage, so the DNA repair mechanisms are less active. As you get older, you have more DNA damage and less capacity to fix it, so that category becomes extraordinarily important."   Dr. Sandra Kaufmann The Science of Slowing Aging

"Aging consists of seven categories of things that happen to your cells. No. 1: Changes to DNA, including epigenetic modification and telomere length. ... Resveratrol and pterostilbene score in every category but do especially well with metabolic pathways and DNA and protein repair. ... NAD (in the form of nicotinamide riboside) is a multi-tasker that is essential in activating the sirtuin pathways and is also vital in DNA repair. "   Dr. Sandra Kaufmann The Science of Slowing Aging

As we age our protection and nutrition of our DNA becomes more and more important. It will pay you to learn how to do this increasingly important task. One fun fact emerges our old friend EXERCISE and its partner in the mists of time FASTING are very important to your DNA continuing to keep you going in fine form. While you are studying your DNA be sure to understand how your epigenome modifies the expression of  your DNA on the way to constructing your body.

 

What May Damage Your DNA

"On a daily basis, our DNA is under attack from numerous sources, including radiation, oxidative stress, environmental hazards, and dietary carcinogens. The extent to which DNA damage occurs—or can be prevented—correlates closely with how long we will live. One course of action is to protect ourselves with compounds that can prevent DNA damage before it leads to cancer. ... Xanthohumol, a compound found in hops, has now been shown in human and animal studies to significantly reduce DNA damage induced both by natural chemical stresses, as well as by some notorious dietary carcinogens. In addition, chlorophyllin and watercress have been shown to reduce DNA damage via several mechanisms. Fortunately, science has identified powerful nutrients that protect against DNA damage and its consequences"   Protect against DNA damage

“Nonlinear resonance, however, is capable of such damage and this sheds light on the genotoxic effects inherent in the utilization of THz waves upon living tissue. The team emphasizes in their abstract that the effects are probabilistic rather than deterministic. Unfortunately, DNA damage is not limited only to THz wave exposure. Other research has been done that reveals lower frequency microwaves used by cell phones and Wi-Fi cause some harm to DNA over time as well.”    Single- and double-strand DNA breaks in rat brain cells after acute exposure to radiofrequency electromagnetic radiation.

"Ultraviolet (UV) light produces DNA damage that plays an important role in causing a variety of diseases. When scientists exposed cells in culture first to UV light and then to blueberry extracts, they found both a reduction in reactive oxygen species and reduced DNA damage.42 Closer examination showed that cells were protected even after DNA damage had occurred, the mechanism being related to decreased genetic expression of stress-induced signaling proteins. This study showed that blueberry anthocyanins protect DNA from damage and protect cells from the consequences of DNA damage that did occur."    Blueberries Boost Longevity Beyond Calorie Restriction

"In a study 9 men received zinc depleted diets for 42 days. DNA strand breaks increased by an average of 57% by the end of the period, indicating that six weeks of reduced zinc intake significantly increases DNA damage in peripheral blood cells. These increases proved reversible by restoring adequate zinc."   Linus Pauling Institute

“We have to figure out why our patients did not get well. Sometimes it can be something as crazy as they lived close to a cell phone tower. We got the patient to move, she did not die and is doing great.”   Doctor Nicholas Gonzales MD, Cancer Specialist, Note here it is folks right from the horses mouth, One likely damage mechanism is the DNA damage from Genotoxic Effects – RFR and ELF DNA Damage

"One mechanism involved in cancer development is oxidative stress and the DNA damage that it causes. Selenium is a natural element capable of fighting oxidative stress and has been shown to be effective in preventing cancer and the biochemical changes that precede it."   Selenium and Cancer Prevention   Note WOW!

"The researchers studied toxicity mechanisms of four different Roundup formulations in human cells. The formulations were diluted at minimal doses (up to 100,000 times or more), but they still caused cell death within a few hours. The researchers also noted membrane and DNA damages, and found the formulations inhibit cell respiration." Chemical Research in Toxicology January 2009;22(1):97-105, Note here is the coming cancer epidemic

"Lemon balm can boost levels of the superoxide dismutase (SOD), an essential component of the body’s native ability to protect itself from the effects of ionizing radiation and other major chemical stresses.19  Lemon balm defends lipid cell membranes in living organisms, as shown by a sharp reduction in the lipid peroxidation that is a measure of direct cell damage following radiation exposure.19 Lemon balm also protects DNA, as shown by a reduction in the amount of the plasma marker 8-OH-dG, a product of oxidized DNA damage.19,21 "   Cancer Risks Of CT Scans

“Obviously, melatonin’s ability to protect DNA from oxidative damage has implications for many types of cancer, including leukemia, considering that DNA damage due to free radicals is believed to be the initial oncostatic event in a majority of human cancers.”  Cerutti et al., 1994

As the above make clear several Causes of DNA Damage are apparent. IMO do all you can to eliminate or at least minimize your exposure to these toxic actors.

  

Gene Expression and Grape Seed Extract and the OPCs

"Resveratrol supplied sirtuins can stabilize chromosomes and DNA molecules, preventing breaks and damage that can lead to cancer, they promote DNA repair and they regulate genetic functions that in turn control every activity in the living cell." Life Extension

"Resveratrol, may be able to help regrow telomeres and aid in slowing down aging. Shuler said he takes a resveratrol supplement that is equivalent to drinking 1,000 bottles of wine a day.”   Doctor Ronald Shuler DDS

”Resveratrol mimics tyrosine, a naturally occurring amino acid that binds to enzymes. One such enzyme, TyrRS, is activated when resveratrol binds to it, causing it to move to the cell nucleus where it helps protect chromosomes' DNA from genetic damage. Such protection, the researchers say, includes tumor-suppressing anti-cancer benefits as well as the ability to increase longevity and fight illnesses that develop with age.(5)  "   Resveratrol protects DNA, cuts risk of heart disease, cancer

"GSE favorably influence expression of genes involved in cellular aging, giving them a broad array of multitargeted benefits."   Life Extension

GSE accomplishes, in part, its vast array of benefits by protecting your DNA structure and altering your gene expression. Make sure you have sufficient vitamin D to allow this process to take place.

Resveratrol an OPC is shown to be very protective and reparative of your DNA. GSE is the poor mans resveratrol.

  

Smart Meters and Radiation can Damage DNA and many Other Body Parts

Almost Everything you have been told (by official sources) about "Smart Meters" is probably wrong, outdated, half-truth, misleading or disingenuous

     

OPCs and Your Endothelium

The OPCs are very protective and reparative of your endothelium. OPCs protect your endothelium from glycation.

The OPCs protect your collagen, a base membrane of many tissues, from oxidation, OPCs are a class of antioxidant plus it will pay you to be very familiar with IMO. Once your learn the manifold benefits and multiple sources of the OPCs it may alter your eating habits, at least it has mine.

   

Actors/Actions that May Damage Your DNA

"Other research has been done that reveals lower frequency microwaves used by cell phones and Wi-Fi cause some harm to DNA over time as well.”    Single- and double-strand DNA breaks in rat brain cells after acute exposure to radiofrequency electromagnetic radiation.

As you can see be very careful with Radiation especially Medical Radiation. Your wonderful Cell Phone and its infrastructure. Other Radiation is also to be watched and minimized. Power is to be contained in WIRES and not blasted into our bodies.       

    

Nutrients that Can Help Prevent/Repair DNA Damage

Green tea protects against many age-accelerating factors, particularly DNA damage, while also promoting DNA repair. These systems work with extreme precision to identify, remove, and heal damaged DNA.3,4 A recent analysis showed that green tea polyphenols have 200 human target genes, including those involved in inflammation, cancer, diabetes, neurodegenerative, muscular, and cardiovascular disease.5 In addition, green tea supplementation has been found to significantly reduce the risk of diabetes, stroke, and depression and improve blood levels of cholesterol and glucose.6 "   Green Tea

"In a study 9 men received zinc depleted diets for 42 days. DNA strand breaks increased by an average of 57% by the end of the period, indicating that six weeks of reduced zinc intake significantly increases DNA damage in peripheral blood cells. These increases proved reversible by restoring adequate zinc."   Linus Pauling Institute

"Resveratrol supplied sirtuins can stabilize chromosomes and DNA molecules, preventing breaks and damage that can lead to cancer, they promote DNA repair and they regulate genetic functions that in turn control every activity in the living cell." Life Extension

"GSE favorably influence expression of genes involved in cellular aging, giving them a broad array of multitargeted benefits."   Life Extension

"Chlorella, a unicellular green algae that has the highest chlorophyll content of any known organism. Chlorella has been shown to protect against DNA damage and telomere shortening due to free radicals,26 to boost the immune system,27 and to protect against environmental dioxin toxins.28."   Takekoshi H, et al

"Lemon balm can boost levels of the superoxide dismutase (SOD), an essential component of the body’s native ability to protect itself from the effects of ionizing radiation and other major chemical stresses.19  Lemon balm defends lipid cell membranes in living organisms, as shown by a sharp reduction in the lipid peroxidation that is a measure of direct cell damage following radiation exposure.19 Lemon balm also protects DNA, as shown by a reduction in the amount of the plasma marker 8-OH-dG, a product of oxidized DNA damage.19,21 "   Cancer Risks Of CT Scans

  • All Antioxidants

  • Blueberries/Bilberries

  • Carotenoids

  • Cocoa

  • Chlorella

  • Chlorophyll

  • Discover and Avoid Radiation Sources   Invisible Slow Death

  • Exercise; Strenuous Exercise

  • Grape Seed Extract and the OPCs

  • Ginseng   IMO take all forms of Ginseng once you pass 40 or so

  • Green Tea

  • Hops

  • Lemon Balm

  • NAC

  • Selenium

  • Watercress

  • Zinc

    

Nutrients that Can Prevent DNA Damage (From Life Extension)

“Obviously, melatonin’s ability to protect DNA from oxidative damage has implications for many types of cancer, including leukemia, considering that DNA damage due to free radicals is believed to be the initial oncostatic event in a majority of human cancers.”  Cerutti et al., 1994

  • Coenzyme Q10 (CoQ10)14-17
  • Coffee and many of its constituents18-20
  • Curcumin21-23
  • Green tea polyphenols, especially epigallocatechin gallate (EGCG)24
  • Indole-3-Carbinol (I3C)25
  • Lycopene26,27
  • Melatonin28
  • Metformin29
  • N-acetylcysteine (NAC)30-35
  • Pomegranate juice and extracts36-38
  • Resveratrol39
  • Selenium40
  • Silibinin and silymarin21,41-47
  • Soybean flavonoids genistein and diadzein 40,47
  • Sulforaphane48
  • Tocotrienols49-53

You should be getting all of these with IMO the exception of anything soy.

       

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

This site was last updated on 24 November 2018 10:26 AM

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