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Lycopene Protocol

    

"There's no question that boosting your lycopene intake has major protective effects. 9"   Life Extension

     

"If you know how to identify the most nutritious tomatoes in the market, you can triple or quadruple your intake of lycopene. Choose tomatoes by color. The darkest red have the most lycopene. Shopping by size is just as important. Small, dark red tomatoes have the most lycopene per ounce and they’re also sweeter and more flavorful. Small tomatoes also have more vitamin C. The smaller-is-better rule applies to varieties within a category.  Tomatoes are better cooked than raw. The longer you cook them, the more health benefits you get. Heat breaks down the cell walls, making nutrients more bioavailable. Second, it twists the lycopene molecule into a new configuration that’s easier to absorb. The most nutritious tomatoes are in the canned goods aisle. Processed tomatoes are the richest source of lycopene. The heat of canning makes lycopene more bioavailable and tomatoes grown for the food industry are picked when red-ripe and processed immediately. No flavor is lost along the way. Tomato paste has up to 10 times the lycopene as raw tomatoes."    Eating On The Wild Side

“Small clinical trials suggest possible benefit in cancer and exercise-induced asthma (11), but no optimal dosage has been established. Epidemiologic studies suggest an inverse relationship between lycopene consumption and risk of cancer, particularly lung, stomach, and prostate. Further, low intake of tomato sauce may be associated with advanced prostate cancer in patients with low grade cancer at diagnosis.” Memorial Sloan-Kettering Cancer Center

“In a study of 1,379 European men those who ate the most lycopene were only half as likely to have a heart attack as men who ate the least lycopene.” University of North Carolina

“Lycopene consumption has been found to decrease not only the risk of prostate cancer in multiple studies but also the risk for breast cancer and pancreatic and stomach cancer as well as lung cancer. Tomato based products are the richest source of lycopene.” Doctor Stephen Strum MD

"We found protective associations of total carotenoid and lycopene intake with hip fracture and non-vertebral osteoporotic fracture over 17 years of follow-up. We found those consuming greater than 4.4 servings per week of lycopene had significantly lower fractures." Journal of Bone and Mineral Research

"People eating tangerine tomatoes in tomato sauce absorbed 200 times more lycopene than those eating regular red tomatoes."  Journal of Agriculture and Food Chemistry, Note IMO always choose the orange tomatoes

"Lycopene has been found in numerous studies to be associated with decreased cancer risk.  Lycopene interferes with cancer cell signaling and disrupts DNA synthesis in growing prostate cell cultures but also protects healthy DNA from damage."   Life Extension

"This study provides evidence that dietary supplementation with lycopene prior to and during the onset of allergic airways disease may be of clinical benefit in reducing eosinophilic infiltrates both in the lungs and systemically,"    Paul Foster et al University of Newcastle, UK

"Researchers followed 54 subjects with moderate uncontrolled high blood pressure. They were already on one or two drugs, with no difference in their pressure. The researchers gave them a tomato extract for six weeks. Their systolic blood pressure dropped by more than 10 mm mercury. The diastolic fell by more than 5 mm. Their lycopene levels rose sharply — 300%. Higher lycopene levels correlated to lower systolic blood pressure.”   Cardiovasc Drugs Ther, 2008 December 4.

 “Participants in the study with higher levels of lycopene display lower levels of C-reactive protein  and the lowest levels of oxidized LDL cholesterol.”   2009 Korean study published in the journal Atherosclerosis

 “In a study to determine silent atherosclerosis those participants found to have carotid atherosclerosis had a body mass index, plasma hemoglobin, and high-density lipoprotein cholesterol that were marginally higher than those diagnosed with without atherosclerosis. All of the nutrients measured were significantly reduced in the atherosclerotic group. Vitamin A, vitamin E, and lycopene levels were decreased by 50 percent or more among those with atherosclerosis compared with participants who were not diagnosed with the condition, and beta-carotene levels were less than a third of those without atherosclerosis. Total cholesterol, low-density lipoprotein cholesterol, triglycerides and C-reactive protein were not significantly associated with carotid atherosclerosis. Riccioni et al, Nutrition & Metabolism , Note cooked carrots addresses all but the vitamin E

“Lycopene consumption has been found to decrease not only the risk of prostate cancer in multiple studies but also the risk for breast cancer and pancreatic and stomach cancer as well as lung cancer. Tomato based products are the richest source of lycopene.” Doctor Stephen Strum MD

“In a study of 1,379 European men those who ate the most lycopene were only half as likely to have a heart attack as men who ate the least lycopene.” University of North Carolina

     

Lycopene an antioxidant (See Antioxidant Protocol) is one of the more than 750 carotenoids (See Carotene Protocol). Lycopene is responsible for the deep red color of several fruits, most notably tomatoes, a tomato must be red, or better still orange, to have lycopene, pink grapefruit (See Grapefruit Protocol) and watermelon (See Watermelon Protocol).

In the body, lycopene is deposited in the liver, lungs, breast, prostate gland, colon and skin (See Skin Protection Protocol). Its concentration in body tissues tends to be higher than all other carotenoids. Tomatoes are a rich source of lycopene. The lycopene in tomatoes can be absorbed more efficiently by the body if processed into juice, sauce, and paste. I often eat cooked carrots (See Carrot Protocol) a good source of all the carotenoids including Lycopene. I also take a 10 mg Lycopene supplement (See Supplement Protocol) about twice a week and eat a good amount of tomato paste.

Since the acid in tomatoes can leach BPA from cans it is best IMO to purchase all your tomato products in GLASS.

      

Tomatoes LOTS of Nutrients besides Lycopene    

Tomatoes, sliced, raw
1.00 cup
(180.00 grams)
Calories: 32
GI: very low

NutrientDRI/DV
 vitamin C33%
 biotin24%
 molybdenum20%
 vitamin K16%
 potassium12%
 copper12%
 manganese11%
 fiber9%
 folate7%
 iron3%
 zinc3%
 choline3%
 protein3%

    

Lycopene important health-promoting mechanisms:5,6 from Life Extension

"On June 9, 2014, PLOS One reported a benefit for lycopene in improving endothelial function in cardiovascular disease patients.* In a double-blind trial, Joseph Cheriyan and colleagues randomized 36 cardiovascular disease patients treated with statin drugs and an equal number of healthy control subjects to receive either 7 mg oral lycopene or a placebo daily for two months. Forearm blood flow assessments of endothelium dependent and independent vasodilation, as well as basal nitric oxide synthase activity, were conducted before and after treatment. In the cardiovascular disease group, endothelial-dependent vasodilation improved by 53% in those who received lycopene compared to those who received placebo. Although it averaged 30% lower in cardiovascular disease patients in comparison with healthy volunteers at the beginning of the study, by the end of the treatment period the endothelial-dependent vasodilation of participants with cardiovascular disease who received lycopene was comparable to that of the healthy subjects at the study’s onset.”   Life Extension   Note this is HUGE take your lycopene!

 

  1. Lycopene facilitates cell-to-cell communication at sites called "gap junctions;" these junctions are essential for cells to know when to stop growing which is key for preventing cancer from developing.
  2. Lycopene stimulates the immune system to help destroy invading microorganisms and early cancer cells.
  3. Lycopene regulates endocrine (glandular) communication pathways.
  4. Lycopene regulates the cell reproductive cycle, preventing cancer development.
  5. Antioxidant

     

High blood levels of Lycopene decreases the risk of many diseases

Higher Lycopene Intake Lowers Risk for Many Chronic Diseases

Higher Lycopene Intake Lowers Risk for Many Chronic Diseases 
Disease Lycopene Indicator Risk Reduction
Death from All Causes Moderate Blood Level 18%71
Overall Cancer Risk Highest Blood Level 45%72
Breast Cancer Highest Intake 74%73
Esophageal Cancer Highest Intake 30%74
Lung Cancer Highest Blood Level Highest Intake 54%75
29%76
Death from Lung Cancer Highest Blood Level 54%77
Death from Oral, Pharyngeal, Laryngeal Cancers Highest Blood Level 47%
(92% in Nonsmokers)78
Ovarian Cancer Highest Blood Level 91%79
Pancreatic Cancer Highest Intake 31%80
Prostate Cancer Highest Intake 82%81
Advanced Prostate Cancer Highest Blood Level 60%82
Cardiovascular Disease (Women) Tomato-based products, 10 or more servings/week 29%83
Cardiovascular Risk Factors (Women) Tomato-based products, 10 or more servings/week High Total Cholesterol: 31% High LDL: 40% High Hemoglobin A1c: 66%84
Atherosclerosis Highest Blood Levels 55%30
Elevated Blood Sugar Highest Intake 43%50
Metabolic Syndrome Highest Intake 45%85
Source Life Extension 

"New research on lycopene, a unique carotenoid, has shown it has an ability to defend against some of the factors of skin aging. Topical application of lycopene combats age-causing free radicals and assists in metabolic functions related to growth and repair."    Topical Lycopene Improves Skin Cellular Function

"We found protective associations of total carotenoid and lycopene intake with hip fracture and non-vertebral osteoporotic fracture over 17 years of follow-up. We found those consuming greater than 4.4 servings per week of lycopene had significantly lower fractures." Journal of Bone and Mineral Research

"Lycopene has been found in numerous studies to be associated with decreased cancer risk.  Lycopene interferes with cancer cell signaling and disrupts DNA synthesis in growing prostate cell cultures but also protects healthy DNA from damage."   Life Extension

"Lycopene in raw tomatoes is poorly bioavailable, and although it is more readily absorbed from processed tomato products (like tomato sauce), many people don't eat enough of these foods to obtain an adequate supply. Studies show that lycopene supplementation holds promise for reducing the impact of aging and many other chronic conditions, through the interactions of its many target effects. Lycopene has been shown to reduce the risk of certain cancers, cardiovascular disease, and metabolic disorders such as diabetes, and neurodegenerative decline."   Life Extension

"A nutrient with significant potential effects against prostate cancer is lycopene, a bright red carotenoid pigment abundant in tomatoes and other red fruits and vegetables.28-30 High consumption of lycopene has been associated with a reduced risk of developing prostate cancer—and also with a reduced risk of dying from the disease. Among men with more aggressive prostate cancers, above-average lycopene consumption was associated with a 59% reduction in the risk of dying from the disease!31 Higher blood lycopene levels have also been consistently associated with reduced prostate cancer risk.32 Additionally, lycopene inhibits the inflammatory processes that promote prostate (and many other) cancers by suppressing critical “master regulatory molecules” such as nuclear factor-kappa beta (NFkB).33 "   Solutions for Common Prostate Problems

  

  • Cancer many types including breast and prostate

  • Cardiovascular Problems

  • Lung Problems

  • Skin Problems

  • Various Eye Problems

     

Lycopene in Foods is Often Poorly Absorbed

"Lycopene is a carotenoid with a unique structure that drives its intense free-radical-trapping activity. Lycopene also operates by additional mechanisms to provide health-giving benefits in the form of cellular communication and cell cycling. The problem is that the fiber content in lycopene-rich foods such as tomatoes interferes with lycopene absorption and bioavailability.2,3 Eating concentrated tomato-based foods like pasta sauce with olive oil provides far greater absorption. Supplementation with lycopene also boosts absorption into the bloodstream, especially when taken with the heaviest meal of the day."   Slash Chronic Disease Risk with LYCOPENE

"People eating tangerine tomatoes in tomato sauce absorbed 200 times more lycopene than those eating regular red tomatoes."  Journal of Agriculture and Food Chemistry, Note IMO always choose the orange tomatoes

"Nutrients that should be taken with the heaviest meal of the day include fish oil, lycopene, lutein, zeaxanthin, gamma tocopherol, astaxanthin and of course vitamin D."   Life Extension

"Adding avocado to salad increased absorption of alpha-carotene, beta-carotene and lutein 7.2, 15.3, and 5.1 times higher, respectively, than the average amount of these carotenoids absorbed when avocado-free salad was eaten. Adding avocado to salsa increased lycopene and beta-carotene absorption 4.4 and 2.6 times higher, respectively, than the average amount of these nutrients absorbed from avocado-free salsa."   WHF

“The processing of tomatoes actually increases the bioavailability of lycopene, an antioxidant that helps neutralize highly reactive and damaging free radicals in the body. Lycopene in tomato paste is four times more available than it is in fresh tomatoes. Canned fish like tuna, sardines, salmon and mackerel are among the best sources of lean protein and omega-3 fatty acids.” Life Extension

Researchers found watermelons stored at room temperature contained 40% more lycopene and  140% more beta-carotene than those that were refrigerated. Why? All the watermelons were ripe when harvested. The melons continued to produce nutrients well after they were picked. Chilling slows down this process. Store your melons outside the frig until ready to eat."  Doctor Victor Marchione MD

Lycopene and all the carotenoids are fat soluble so always eat a little good fat (See Fat Soluble Nutrients Protocol) with them. Pasta sauce with olive oil appears to be an excellent way to get lycopene. Eating lycopene, vitamin D and other foods with the largest meal of the day is a proven way to often maximize nutrient intake.

    

Tangerine tomatoes increase total and tetra-cis-lycopene isomer concentrations more than red tomatoes in healthy adult humans.

The orange tangerine tomato in pasta form with LOTS of olive oil eaten with a full meal may be the way to get your Lycopene

"Both tomato sauces increased lycopene concentrations in blood, but the tangerine tomato sauce caused a greater increase of total and tetra-cis-lycopene. The cis isomer(s) may also have facilitated absorption of the trans-lycopene isomer. Indices of oxidative damage decreased as serum lycopene concentrations increased. Our results suggest that total lycopene concentrations can be increased by substituting tetra-cis-lycopene-rich tangerine tomatoes for common red tomatoes in the diet."    Tangerine tomatoes increase total and tetra-cis-lycopene isomer concentrations more than red tomatoes in healthy adult humans   Note "The tomatoes used for this work were developed specifically for the study – these particular varieties aren’t readily available in grocery stores. The researchers suggest that interested consumers seek out orange- and gold-colored heirloom tomatoes as an alternative to Tangerine tomatoes, but caution that they haven’t tested how much or what kind of lycopene these varieties contain."

   

Sun Dried Tomatoes

"Tomatoes are officially "sun dried" when all the moisture is taken out. At the same time all the nutrients are left in - delivering a super concentrated dose of healthful vitamins, minerals and phytochemicals for which the tomato is justifiably praised."   Healing Spices

85% of lycopene in our diet comes from tomatoes and tomato products. The best lycopene supplements are nothing but a concentrated tomato product. A baseball sized tomato will shrink to the size of quarter. SO IMO the way to get lycopene is with a natural concentrated tomato product; like Sun Dried Tomatoes. Olive Oil can help you increase the lycopene absorption so be sure to include it in any ingestion of lycopene.

   

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http://www.mskcc.org/mskcc/html/69288.cfm#References

   

 

This site was last updated on 24 January 2018 07:05 PM

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