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Grape Seed Extract Protocol

Grape Seed Extract is a Key Supplement

Grape Seed Extract is a Nitric Oxide Super Supplement

Grape Seed Extract is a Polyphenol Super Food

Grape Seed Extract is an OPC

Grape Seed is an Eye Health Food

Grape Seed Extract is a Nrf2 Promoting Super Food

Grape Seed extract is AMPK Promoting

Note: When you see a food/supplement with all these Salubrious Attributes EAT IT OFTEN

Note: GSE can form the base of your antioxidant supplement program

   

Please TAKE this SUPER SUPPLEMENT every day!

   

“GSPE also inhibits atherosclerosis (4) (5). Small human trials have shown possible efficacy in decreasing LDL (6) and increasing total serum antioxidant activity (7).” Memorial Sloan-Kettering Cancer Center

“Grape Seed Extract provided excellent protection against acetaminophen overdose-induced liver and kidney damage.”    Bagchi et al

“In vivo grape seed-skin extract has been shown to have antioxidant action 50 times greater than vitamin E and 20 times greater than vitamin C. The antioxidant protection of grape seed-skin extract extends across the brain-blood barrier to the brain and spinal nerves.”    Bagchi et al

“Supplemental grape seed extract is a good source of resveratrol.”    Life Extension

“While grape polyphenols’ primary mechanism appears to be that of reducing low-density lipoprotein oxidation via their antioxidant property, the compounds also decrease blood clotting, improve abnormal heart rhythms and help reduce narrowing of the blood vessels, possibly through effects on cellular signaling and gene activity.”    Leifert et al 2008

“Grape seed extract is known for its powerful antioxidant qualities. Grape seed extract also acts as a smooth muscle relaxant in blood vessels to combat hypertension.”     Life Extension 

“Grape seed extract preexposure prior to acetaminophen, amiodarone and doxorubicin provided near complete protection in terms of serum chemistry changes and significantly reduced DNA fragmentation. Moderate to massive damage occurred in the liver, kidney, lung and heart tissue by all three drugs in the absence of grape seed extract.”    Ray et al 2000

“Grape seed extract is excellent at treating vascular diseases because it actually increases the structural strength of weakened blood vessels.” Jean Carper

“In nine studies OPC has been shown to be efficacious for varicose veins by strengthening the veins and restoring their resilience so they retract back into the skin. OPC has been shown to reduce fluid build up and swelling due to leaking veins.” Doctor Masquelier OPC Expert et al, Note OPC is found in GSE

“OPC reduces edema and swelling which may be important in fighting HBP, congestive heart failure and sports injuries involving swelling.” Jean Carper, Note OPC is found in Grape Seed Extract 

“In a study of 92 patients with venous insufficiency or varicose veins subjects given 300 mg of grape seed OPC daily for 28 days showed reduced pain, tingling, night leg cramps and swelling by more than 50%, making it twice as effective as the dummy pill.” French Study 1985

In a double blinded study of fifty patients with varicose veins 150 mg of grape seed OPC a day worked faster and longer than a commonly prescribed drug (Diosmine) in reducing pain, sensations of burning and tingling and the degree of distension of the veins.” Italian Study

“Grape seed OPC has also proved good medicine for your eyes. It helps eyes recover from the glare of bright lights. OPC helps relieve eye stress caused by working at a computer monitor and improved the function and sensitivity of the retina in nearsighted people. OPC’s strong antioxidant activity may also make it ideal treatment for age-related macular degeneration.” Jean Carper

“I credit the slowdown in my macular degeneration to first Pycnogenol and then to grape seed extract.  Until my recent retirement I recommended OPC grape seed extract and Pycnogenol to all my patients. I do not know a single patient who did not benefit.” Doctor Madison Dixon, Optometrist

“OPC may help reverse HBP and its consequences. People with HBP commonly have weakened capillaries with high permeability. In animals prone to HBP OPC has strengthened capillaries.” Jean Carper

“Although OPC was never released as a pharmaceutical antihistamine it performs just as well.” Doctor Masquelier, OPC Expert 

“OPC from grape seed is recommended as the preferred form by health care practitioners in France where it outsells Pycnogenol by 400%. The fact that Pycnogenol out sells grape seed extract in the US is due to aggressive marketing.” Doctor Michael Murray, Note the leading work on OPC was done in France

“In a study grape seed extract was found to be as efficacious as the stimulant drugs including Ritalin, usually given for ADD and ADHD in controlling the symptoms of these problems.”  Doctor Marion Sigurdson PhD, Psychologist

"In lab experiments, scientists found that the [GSE] extract stimulated leukemia cells to commit suicide. Within 24 hours, 76% of leukemia cells exposed to the extract were killed off, while healthy cells were unharmed, Clinical Cancer Research reports."  An extract from grape seeds can destroy cancer cells, US research suggests

"Grape seed extract coupled with soy lecithin improve age-related cognitive deterioration and reduce age-related oxidative damage and cerebral amyloid deposition."  Life Extension

"These results suggest that in selected patients with tinnitus and altered perfusion, Pycnogenol is effective in a short period of time in relieving tinnitus symptoms by improving cochlear blood flow,"   Pine Bark Extract Appears to Relieve Tinnitus Symptoms, Note IMO it is worth trying GSE

“Daily supplementation with an extract from French maritime pine bark may boost skin elasticity by 25% and skin hydration by eight percent, says a new study. Twelve weeks of supplementation with Pycnogenol® was associated with increases in skin elasticity and hydration, and an increase in the production of hyaluronic acid in skin by 44%, according to findings published in Skin Pharmacology and Physiology. Hyaluronic acid is a component of the matrix between cells (extracellular matrix) that occurs naturally in the body until the age of about 30, after which levels start to decrease. The decrease is understood to play a role in the aging process, particularly a breakdown in the extracellular matrix, and an increase in the formation of wrinkles.”   Study Unlocks Pycnogenol's Skin Health Mechanism, Note GSE and pycnogenol are similar IMO

    

Grape Seed Extract a super Supplement

"Although OPCs, procyanidolic oligomers exist in many plants, commercially available sources of PCOs include grape seed extracts and extracts from the bark of the maritime pine (Pycnogenol)."   Doctor Michael Murray N.D, Note here it is folks GSE is THE replacement for Pycnogenol

Grape Seed Extract is a powerful anti-oxidant, anti-aging, anti-bacterial, anti-cancer, anti-viral, anti-inflammatory, anti-histamine, anti-biotic, anti-tumor, anti-diabetic, anti-ulcer, pro-heart and arteries, and anti-brain aging, supplement. It has been shown to help many health problems. Grape Seed Extract is able to pass your blood brain barrier (See Blood Brain Barrier Protection Protocol) and thus is available to your brain  and central nervous system. It stays active in your body for a full three days. Folks this is a prime supplement please TAKE this SUPPLEMENT, every day.

Grape seed extract contains a flavonoid, OPC, which has been shown to retard collagen and elastin oxidation. It thus acts to reinforce and strengthen all body structures incorporating these building blocks; most noticeably your vascular system. But ladies please note your facial tissue and the firmness you your breast and derriere tissue also depends on collagen and elastin. 

   

Grape Seed Food Sources 

The active ingredients in Grape Seed are found most plentifully in Muscatine grapes and to a much less extent in other dark skinned grapes. It is also found in plums, blueberries  and Cranberry. Quercetin may help Grape Seed be better absorbed. Be sure to crush and eat all the seeds of grapes and other plants and fruit.

   

Resveratrol®

"Just recently, Life Extension reported that experimental animal studies conducted by BioMarker Pharmaceuticals were under way using the same grape extract fortified with resveratrol that is currently used by Foundation members.6  ... These findings paved the way for further analysis identifying the specific molecular pathways involved in these effects. Here we provide an update to these earlier findings."   What Dose of Resveratrol Should Humans Take?

Grape Seed Extract is the poor mans Resveratrol®.  Resveratrol® is a propriety form of OPC. However Resveratrol’s® bioflavonoid concentration is 85% while that of grape seeds' often is higher.  Both grape seed extract and resveratrol® contain the flavonoid OPC.

Resveratrol has attained superstar status in the supplement world. There are few benefits not attributed to OPC. IMO load  up on the vastly more inexpensive GSE also with it's OPC.

   

Pycnogenol

“OPC from grape seed is recommended as the preferred form by health care practitioners in France where it outsells Pycnogenol by 400%. The fact that Pycnogenol out sells grape seed extract in the US is due to aggressive marketing.”    Doctor Michael Murray, Note the leading work on OPC was done in France. This shows that many of the demonstrated benefits of Pycnogenol are probably available with the more economical grape seed extract . I use GSE. For serious problems I would use BOTH just in case.

"Another benefit of improved blood flow is better erectile function in men. A dramatic study showed that a combination of L-arginine aspartate and Pycnogenol® intake for one month restored erectile dysfunction to normal, and doubled the frequency of intercourse.25 Along the way, cholesterol and blood pressure were also reduced."   Pycnogenol Benefits . Note GSE will probably supply this benefit also

Resveratrol, Grape Seed Extract and Pycnogenol are all rich in OPCs, procyanidolic oligomers. There is extensive research on the manifold salubrious benefits for all three. The inexpensive GSE is my favorite and I use a LOT. Note ALL the above substances are all RENOWNED health promoting and have been so known for a LONG time.

   

OPCs and Your Endothelium and Blood

"Your capillaries are the smallest element of the blood circulation system – but maintaining them delivers the biggest benefits. ... Jack Masquelier discovered two plant extracts that help fight ageing – and therefore the decline – of blood vessels and capillaries. In doing so he provided a means by which you can maintain vitality as you age. His extracts stimulate blood flow and help against the damaging effects of free radicals. The beneficial effects can be felt throughout your entire body, from the tips of your toes to the top of your head, including your eyes and skin."   Aging & blood vessels   Note OPCs can help your capillaries produce good Nitric Oxide which will help keep your blood flowing freely

The OPCs are very protective and reparative of your endothelium. OPCs protect your endothelium from glycation. Every artery in your circulation system is lined with endothelial cells. The OPCs protect your endothelium from glycation. Your endothelium is the interface between your flowing blood and the rest of your body and supplies many factors which affect blood coagulation.

The OPCs protect your collagen, a base membrane of many tissues, from oxidation, OPCs are a class of antioxidant plus it will pay you to be very familiar with IMO. Once your learn the manifold benefits and multiple sources of the OPCs it may alter your eating habits, at least it has mine.

   

Gene Expression and GSE

"Resveratrol supplied sirtuins can stabilize chromosomes and DNA molecules, preventing breaks and damage that can lead to cancer, they promote DNA repair and they regulate genetic functions that in turn control every activity in the living cell." Life Extension   Note this is EXACTLY what we want, take your Resveratrol/Grape Seed Extract DAILY

"Resveratrol, may be able to help regrow telomeres and aid in slowing down aging. Shuler said he takes a resveratrol supplement that is equivalent to drinking 1,000 bottles of wine a day.”   Doctor Ronald Shuler DDS

”Resveratrol mimics tyrosine, a naturally occurring amino acid that binds to enzymes. One such enzyme, TyrRS, is activated when resveratrol binds to it, causing it to move to the cell nucleus where it helps protect chromosomes' DNA from genetic damage. Such protection, the researchers say, includes tumor-suppressing anti-cancer benefits as well as the ability to increase longevity and fight illnesses that develop with age.(5)  "   Resveratrol protects DNA, cuts risk of heart disease, cancer

"GSE favorably influence expression of genes involved in cellular aging, giving them a broad array of multitargeted benefits."   Life Extension

GSE accomplished its vast array of benefits by altering your genes. Make sure you have sufficient vitamin D to allow this process to take place.

   

Grape Seed Extract Benefits

"GSE holds promise not only in preventing hypertension but also in fighting some of its deleterious effects such as kidney damage. GSE has many mechanisms to lower HBP."   Life Extension

"Another benefit of improved blood flow is better erectile function in men. A dramatic study showed that a combination of L-arginine aspartate and Pycnogenol® intake for one month restored erectile dysfunction to normal, and doubled the frequency of intercourse.25 Along the way, cholesterol and blood pressure were also reduced."   Pycnogenol Benefits . Note GSE will probably supply this benefit also

"The cardiovascular health benefits of grape seed extract include favorable effects on blood pressure, enhanced endothelial function, and decreased oxidative stress.8 The potent antioxidant activity of grape seed extract may be responsible for its reported neuroprotective effects, as observed in animal models of Alzheimer’s disease.9,10 Recently, grape seed extract combined with calcium was found to be more effective than calcium alone in building healthy bone mass.11 Grape seed extract has effectively inhibited the growth of human colorectal tumor cells in the laboratory and in animals.12"   What Dose of Resveratrol Should Humans Take?

"After searching for natural, deep vein thrombosis-inhibiting interventions, scientists identified two ingredients that demonstrated powerful preventive effects: Nattokinase, an enzyme extracted from soybeans fermented with the bacterium Bacillus natto, and French maritime pine bark, a natural extract rich in polyphenols. ... Nattokinase and pine bark extract were shown to work together to prevent clots as well as to improve the microcirculation of the legs."   Natural Approach to Guard Against DVT   Note GSE can be used in place of French maritime pine bark

“In vivo grape seed-skin extract has been shown to have antioxidant action 50 times greater than vitamin E and 20 times greater than vitamin C. The antioxidant protection of grape seed-skin extract extends across the brain-blood barrier to the brain and spinal nerves.”    Bagchi et al

“Grape seed extract is excellent at treating vascular diseases because it actually increases the structural strength of weakened blood vessels.” Jean Carper

“OPC reduces edema and swelling which may be important in fighting HBP, congestive heart failure and sports injuries involving swelling.” Jean Carper, Note OPC is found in Grape Seed Extract 

“Grape seed extract also acts as a smooth muscle relaxant in blood vessels to combat hypertension.”     Life Extension 

“Supplemental grape seed extract is a good source of resveratrol.”    Life Extension

 

     

What Dose of Resveratrol Should Humans Take?

"Resveratrol and grape extract produce strongly similar effects, based on the gene-expression responses demonstrated in mice fed a relatively low dose of these compounds. Comparison of these groups with calorie-restricted mice shows a significant overlap in the three treatments’ regulation of similar biological pathways. These data add to the accumulating evidence that resveratrol triggers a biological response in mammals that is similar to that observed with caloric restriction, an intervention that is known to extend life span and protect against age-related diseases.2-5 These effects are observed even at a relatively low dose of resveratrol, indicating that a human-equivalent dose can be obtained through dietary supplementation with high-quality resveratrol products."   What Dose of Resveratrol Should Humans Take?

Above Life Extension explores the doses of Resveratrol required to achieve certain salubrious body states. You can translate this into GSE requirements. IMO the gram equivalence between can be considered to be about one to one. You may want to take more resveratrol.

    

OPC for Sunburn Protection

Figure 1. Pycnogenol Prevents Sunburns In Humans   (Source Life Extension)

I take at least 100 mg of Grape Seed Extract as my chief anti-oxidant supplement, usually every day.

  

Quercetin is Close Chemically to Resveratrol

Quercetin, a close chemical relative of resveratrol and a member of the Vitamin C Complex, is present in a variety of fruits and vegetables, tea and red wine.IMO it's worth making sure you get LOTS of quercetin for this reason alone. Be sure to take some quercetin with your resveratrol as it helps your body to absorb the resveratrol. Quercetin is a member of my Vitamin C Complex so I supplement it every day.

  

Conclusion

GSE, Resveratrol , Quercetin,  Pycnogenol and the OPCs are MUST have foods and supplements EVERY DAY IMO.  Please take resveratrol or its close relative grape seed extract or both every day. Especially if you are over 40 or so. Many foods and supplements can help GSE and resveratrol in their important CVD and other functions.

    

ALSO SEE

Pycnogenol Protocol

Resveratrol Protocol

Quercetin Protocol

OPC Protocol

    

More on Grape Seed Extract:

http://www.grapeseedextract.com/

http://www.lef.org/magazine/mag2005/jul2005_report_grapeseed_01.htm

http://www.bodybuildingforyou.com/health-supplements/grape-seed-extract.htm

 

 

 

 

 

This File was last updated on 05 February 2020 01:48 PM

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