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Natural Killer Cells Protocol

"Natural killer cells (NK cells) are lymphocytes that are part of nonspecific resistance.  They recognize and destroy abnormal cells such as cancer cells and cells infected with viruses. Recognition of such cells involves a complex process of identifying inhibitory and activating molecular markers on the surface of the target cell. Molecular markers that make up the major histocompatibility complex (MHC) are expressed by healthy cells. Cancer cells and virus-infected cells actively diminish or eliminate expression of MHC markers on their surface. When a NK cell recognizes a decrease in inhibitory normal MHC molecules and an increase in activating molecules on the surface of a cell, the NK cell will be activated to eliminate the cell in distress.  Once a cell has been recognized as a target, the NK cell destroys it."   NK Cells and Phagocytosis

"Natural killer (NK) cells are large granular lymphocytes of the innate immune system, responsible for direct targeting and killing of both virally infected and transformed cells. Under pathological conditions and during inflammation, NK cells extravasate into the lymph nodes and accumulate at inflammatory or tumor sites. The activation of NK cells depends on an intricate balance between activating and inhibitory signals that determines if a target will be susceptible to NK-mediated lysis. Many experimental evidences indicate that NK cells are also involved in several immunoregulatory processes and have the ability to modulate the adaptive immune responses. Many other important aspects about NK cell biology are emerging in these last years. The aim of this review is to elucidate the role of NK cells in tumor angiogenesis and their interaction with mast cells. In fact, it has been observed that NK cells produce pro-angiogenic factors and participate alone or in cooperation with mast cells to the regulation of angiogenesis in both physiological and pathological conditions including tumors."   Cross talk between natural killer cells and mast cells in tumor angiogenesis

"Natural Killer (NK) cells are innate lymphocytes playing pivotal roles in host defense and immune-surveillance. The homeostatic modulation of germ-line encoded/non-rearranged activating and inhibitory NK cell receptors (NKRs) determines the capability of these innate lymphocytes to either spare “self” cells or to kill viral-infected, tumor-transformed and heterologous cell targets."   On the Way to Become a Natural Killer Cell

"The first line of defense against new invaders is our natural killer (NK) cells. NK cells come fully equipped to recognize any cells that don’t belong in your body.65 Such cells include those whose replicative machinery has been taken over by a virus, and also cells that have gone rogue to replicate without natural controls, such as cancer cells.16. As we age, NK cells lose their functionality, thus leaving us far more vulnerable to viral diseases—and the formation of tumors.9,10 Aging humans don’t have to succumb to this massive loss of NK cell function. Scientists have uncovered an enzymatically modified rice bran that has been shown to increase NK cell activity in circulating blood cells by up to 84%!11"   Activate Your Natural Killer Cells

"Natural killer cells (NK cells) are one of your body’s most powerful defenses against infections and cancer.13-15 These tiny security guards seek and destroy cells that have been transformed by an infection with a virus or by one of many malignant changes that transform them into cancer cells.9,16 NK cells work by triggering apoptosis (programmed cell death) in cells that have been transformed by a virus or malignancy.17,18 Without this critical defense mechanism, viruses can be spread throughout the body and cancer cells can form invading, metastasized tumors.9,19 The health of these cells is critical to a robust immune system. Unfortunately, your NK cell function rapidly declines as part of the natural decline in your immune system as you age.20-22 This degeneration of immune function is medically termed immune senescence."   Activate Your Natural Killer Cells

"A review article entitled Opioid Therapy for Chronic Pain, published in a 2003 issue of the New England Journal of Medicine, states: Opioid-Induced Immune Modulation: .... Preclinical evidence indicates overwhelmingly that opioids alter the development, differentiation, and function of immune cells, and that both innate and adaptive systems are affected. Bone marrow progenitor cells, macrophages, natural killer cells, immature thymocytes and T cells, and B cells are all involved. The relatively recent identification of opioid-related receptors on immune cells makes it even more likely that opioids have direct effects on the immune system."   Doctor Joseph Mercola ND, Note here is another reason to exercise which produces the natural opioids we know as endorphins

“Supplementing with selenium, 200mcg/day in individuals with normal blood levels of selenium resulted in a 118% increase in the ability of lymphocytes to kill tumor cells and an 82% increase in the activity of natural killer cells.” Roy, Note "normal" is often suboptimal due to the poor health status of the "normal" person

“The study showed that severe vitamin E deficiency causes impaired NK cell activity but that the condition is reversible with alpha-tocopherol supplementation.”  Adachi et al, Note NK, natural killer, cells are a main component of your passive immune system

"Studies suggest that Siberian Ginseng may help reduce blood sugar levels, balance blood pressure levels, and enhance the immune system by boosting the body's production of natural killer cells."  Siberian Ginseng

“The study showed that severe vitamin E deficiency causes impaired Natural Killer cell activity but that the condition is reversible with alpha-tocopherol supplementation.”  Adachi et al

“Oral L-Glutamine in rats upregulated tissue glutathione, increased natural killer cell activity and tumors were inhibited.”  Klimberg et al   Note want a good immune system?

“If your body has inadequate zinc stores, you will experience increased susceptibility to a variety of infectious agentsYour white blood cells simply can't function without zinc. Zinc affects multiple aspects of your immune system, including neutrophils, natural killer cells, phagocytosis, cytokine production, antibody production, and even gene regulation within your lymphocytes. Zinc is involved in many basic cellular functions including DNA replication, RNA transcription, cell division and activation, and stabilization of cell membranes.”   Zinc is a Key Mineral for Your Immune Health

"Beta-1,3 glucan has incredible immune building power. And mushrooms are one of the richest sources on earth! Medicinal mushrooms are proven in numerous medical studies to increase the number and activity of Natural Killer (NK) cells in your body.”   Doctor Nan Fuchs PhD

"A unique product, enzymatically modified rice bran (EMRB), has now been developed, EMRB boosts NK cell activity by nearly 84%. EMRB is also effective at reducing deaths from certain cancers, further testimony to its boost of NK function.  ... An especially promising early animal study demonstrated the power of EMRB for boosting NK cell activity. When old mice with age-related reduction of NK function were injected with EMRB, they showed a greater than five-fold increase in NK cell activity within just two days of treatment.46 The enhanced NK activity in this study also resulted in increased binding of NK cells to target tissues and boosted the amounts of cell-killing chemicals inside each cell. The wintertime viral season is precisely the time that this product should be used for optimum protection. ,,, Once the flu season is over, you can stop the EMRB supplement until next year’s season begins. All-year immune support can be obtained by supplementing with other immune enhancers such as Cistanche and Reishi that provide broad-spectrum immune support, including enhanced NK cell activity. "    Activate Your Natural Killer Cells

"The first line of defense against virus-infected28-31 and cancer cells is our natural killer cells.32-45 Young individuals have high levels of functional natural killer (NK) immune cells, but this declines with aging. 46-49 In elderly subjects, decreased NK cell activity is associated with an increased incidence and severity of viral infections such as shingles, influenza, and cytomegalovirus (CMV). 47,50-53 Natural killer cells originate in the bone marrow (like other immune cells) and go through a maturation process that enables them to participate in early control of microbial infections and cancers.47,62 "   How Immune Decline Hastens Aging

"The immune-boosting properties of Reishi mushrooms have been appreciated in Eastern medicine for thousands of years. Modern science is just now beginning to validate their health-promoting properties. Studies show that consuming these mushrooms improves immune function and has anti-tumor effects.9-16 In mice, Reishi has been found to promote the maturation and activation of immune system cells such as T cells, natural killer cells, dendritic cells, and macrophages.10-13 Lab studies show that Reishi also helps raise protective IL-10 levels and lower pro-inflammatory IL-6 levels. This indicates that Reishi augments the function of both the innate and adaptive immune system. The innate immune system can be thought of as the body's first line of defense, responding rapidly to potentially harmful insults such as viruses, bacteria, and cancer cells. Natural killer cells are an important component of this innate immunity.19-24 The diminished numbers of active natural killer cells that can occur with aging predispose an individual to high rates of infection by viruses ranging from the common cold to herpes viruses. The adaptive immune system acts slower than the innate immune system but mounts a more specific, powerful attack against pathogens using specialized immune system cells called T cells."   Restore Youthful Immune Function

"Natural killer cells are the body’s first responders against viral infections and cancer cells, and play an important role in battling bacterial and fungal infections.19-24 The age-related decline in the function of natural killer cells leads to higher rates of many viral, bacterial, and fungal infections—and these infections are more likely to be serious in age-related immune senescence. For example, research shows that the common cold (which is caused by a virus) is more frequent in individuals with low numbers of natural killer cells—and conversely, that greater natural killer cell function helps protect against viral outbreaks. The decline in natural killer cells has also been shown to increase the rates of viral infections, including viruses that cause influenza and viruses in the herpes family.26 These include cytomegalovirus (CMV), Epstein-Barr virus, varicella zoster (which causes chicken pox and shingles), and herpes simplex viruses (causing oral and genital herpes). Compounding the problem, cytomegalovirus (CMV) itself may directly contribute to the loss of immune function.46,47 In one study, higher levels of CMV in older women correlated with an increased five-year risk of all-cause mortality."   Restore Youthful Immune Function

"These responses [Inducible Nonspecific Responses] including fever and release of class 1 interferons (alpha and beta) are activated when infectious agents manage to invade and they are particularly effective in preventing viral replication [Natural Killer Cell effectuators]"   Medical Immunology 5th Ed    Note Bovine Interferons (bio identical to human) can do this job; Kick your Innate Immune System, including NK Cell action, into action with fever and interferon.

       

Here we see how a defective cell is identified by a Cytotoxic T Cell (CTL)  and destroyed by a NK cell

Your innate immune system's Natural Killer Cells provide immediate invader killing power for your immune system. It is not too hard to think of these IMPORTANT parts of your immune system when supplementing.  Vitamin D and vitamin C are required in good amounts for a strong NK response. There are many other ways to strengthen your NK response. DO THEM especially if you are getting  up in age.

The lack of vitamin D and to some degree vitamin C, accounts for much of our susceptibility to contacting the seasonal flu all other viral, bacterial and infective diseases. Since our population is severely deficient in Vitamin D and Vitamin C IMO use these at the onset of flu season, September, as a reminder to get  your vitamin D and C UP. The worthless and dangerous "flu shot" cannot help but the anti-infective Vitamins especially Vitamin D will prevent all serious flu and other viral infections.

Several vitamins and supplements are NK response enhancing and IMO you should assure they aid your NK response.

If you use Enzymatic Modified Rice Bran (IP6) an inexpensive very salubrious supplement during the flu season you will be doing your innate immune system a favor.

    

Vitamin D and Natural Killer Cells

The simple primal act of getting noontime sun on your bare “unprotected” skin in large amounts just may be the most important single thing you can do for your health. 

The simple primal act of getting LOTS of the high noon sun on your bare “unprotected” skin in large amounts just may be the most important single thing you can do for your health. If the sun casts a shadow longer than you are tall you cannot make adequate vitamin D from the sun. You MUST take vitamin D3 at the daily rate of about 1000 IU/20 pounds of body weight.  Vitamin D Expert Doctor Holick’s Excellent Entertaining Amusing Video Vitamin D Presentation

IMO get an hour or more of noontime sun/day in season or 1000 IU of vitamin D3/20 pounds body weight/day

     

Don’t be afraid of Sunshine, Vitamin A, Vitamin C, Vitamin D or Cholesterol; learn their properties and safely and freely use these powerful health tools

"It is high time that worldwide vitamin D nutritional policy, now at a crossroads, reflects current scientific knowledge about the vitamin's many benefits and develops a sound vision for the future.”   Doctors Norman and Bouillon 

"Cedric Garland, DrPH, and colleagues selected 32 studies that provided data on a total of 566,583 men and women for their analysis. They determined that having a vitamin D level of 30 ng/mL is associated with approximately half the risk of dying over an average nine years of follow-up in comparison with lower levels. Dr. Garland, who is a professor at UC San Diego, noted that serum levels of vitamin D lower than 30 ng/mL are estimated to exist in two-thirds of the US population. Life Extension continues to recommend that people maintain 25-hydroxyvitamin D blood levels between 50-80 ng/mL."   Review Affirms Higher Vitamin D Levels Are Associated With A Reduced Risk Of Premature Mortality   Note if you truly want a great Vitamin D level shoot for at least 65 ng/ml

"Without sufficient amounts of vitamin D the cell cannot access it's DNA library and its functions are thereby impaired. The cell needs vitamin D to make the tools that are needed for everyday activity. This is why vitamin D can function in so many tissues and affects so many different diseases and health conditions."  Doctor Robert Heaney Vitamin D Researcher

"If you want to maintain a level of 32 ng/ml you need to ingest 4,000 IU of vitamin D3/day. IMO the upper safe dose is 10,000 IU a day. If you have a serious health problem these large doses are not going to hurt."   Doctor Robert Heaney Vitamin D Researcher

The lack of vitamin D and to some degree vitamin C, accounts for much of our susceptibility to contacting the seasonal flu all other viral, bacterial and infective diseases. Since our population is severely deficient in Vitamin D and Vitamin C IMO use to onset of flu season, September, as a reminder to get  your vitamin D and C UP. The worthless and dangerous "flu shot" cannot help but the anti-infective Vitamins especially Vitamin D will prevent all serious flu and other viral infections.

Dozens of our body’s systems depend on vitamin D. Low levels of vitamin D contributes, is often a MAIN factor, in hundreds of diseases. Many diseases are more prevalent the farther north or south you get from the equator.  For example without vitamin D you cannot build bone no matter how many calcium pills you pop or how much milk you drink. Sure enough osteoporosis is more prevalent the farther north or south you get from the equator. Vitamin D boosts your production of cathelicidin which your natural killer cells use to destroy microbes. Without vitamin D your immune system will operate on a much lower response level allowing disease to get a foothold in your body. Doctor Heaney explains why this is so. 

As doctor Heaney says you need about 32 ng/ml just to access your genome. The vitamin D must be operating to correctly create your epigenome. About 85% of us have less than this. IMO this may account for MANY of the "health problems" we are experiencing in today's world of artificial food and deceitful, treasonous, senseless, pernicious noon sun avoidance. What they have given us with this sun avoidance crap is the inability to correctly read our genome. Thanks CDC!

  

Interferon, Interleukins and Natural Killer Cells

"An effective primary cytotoxic T-cell is seldom deployed in less than a few days and may  take as long as two weeks. During this time the host depends on defenses that can be deployed much more rapidly; such as the production of type 1 interferons (alpha and beta), initiated as soon as the virus starts replicating and the activity of natural killer cells. These two effector systems are closely related; type 1 interferons activate NK cell functions. both are particularly effective as defenses against viral infections."   Medical Immunology 5th Ed  

"These responses [Inducible Nonspecific Responses] including fever and release of class 1 interferons (alpha and beta) are activated when infectious agents manage to invade and they are particularly effective in preventing viral replication [Natural Killer Cell effectuators]"   Medical Immunology 5th Ed    Note Bovine Interferons (bio identical to human) can do this job; Kick your Innate Immune System, including NK Cell action, into action with fever and interferon.

"IL-12 [Interleukin 12], produced at the same time as interferons alpha and beta, is believed to play a critical role in the early activation of NK cells."   Medical Immunology 5th Ed  

"NK cells express the FeygRIII, a low-affinity Fc receptor that binds IgG-coated cells, IgG binding results in their activation of the NK cell and lysis of the target, a process known as antibody=dependent cellular cytotoxicity (ADCC) ADCC-dependent activation and killing is not inhibited by the NKIR inhibitory receptor."    Medical Immunology 5th Ed  

Interferons and Interleukins prime your natural immune system and your Natural Killer Cells to expeditiously do their job of eliminating pathogens, especially viruses and virus infected tissue from your body. You can work to improve your production of interferon. IMO supplement the bio-identical bovine interferon when seriously coming down with something nasty.

    

Aging and Natural Killer Cells

"Unfortunately, your NK cell function rapidly declines as part of the natural decline in your immune system as you age.20-22 This degeneration of immune function is medically termed immune senescence."   Activate Your Natural Killer Cells   Note there is no "natural" decline in NK Cells, a critical component in your immune system IF YOU do a few simple things EXERCISE is one.

"Healthy NK function is critical in eliminating transformed cancer cells.27,44,63 NK cells are also involved in the elimination of senescent cells62,64 that otherwise cause chronic inflammation.27,65-67 The age-related decrease in functional NK cells is likely to have wider implications for the health of older adults than currently understood by the mainstream. If an aging person is to better manage debilitating and deadly infections and malignancies, maintaining youthful NK function is critical."    How Immune Decline Hastens Aging

"Evidence has emerged that has shown that in addition to eliminating transformed cells, NK cells are involved in many other biological processes such as immune regulation, antimicrobial immune responses, and the recognition and elimination of senescent cells… Thus, the decrease in NK cell function that accompanies physiological aging is likely to have wider implications for the health of older adults than originally thought.”   Aging Research Reviews-May 6, 2013. “The Impact of Aging on Natural Killer Cell Function and Potential Consequences for Health in Older Adults.”

"When you were younger, your NK cells, which are part of your innate immune system, could destroy the new strain of virus while your adaptive immune system “learned” its properties and then made antibodies to destroy any remaining virus.30-33 But because your NK cell function declines with age, you can easily be rapidly overwhelmed by new viral strains before your slower adaptive immunity can develop. Similarly, older adults are at an increased risk of cancer because falling NK function fails to destroy malignant cells early on, allowing them time to develop various tricks that evade adaptive immunity while they grow into life-threatening tumors. Younger people have more robust NK function, which helps explain why cancers are generally so rare before late middle age. "   Activate Your Natural Killer Cells

"Shingles occurs when our immunity to dormant chickenpox viral infection declines. It manifests as an extremely painful skin lesion that can last for months. 54 Influenza, commonly called the flu, is a virus that inflicts its lethal effects mostly on the elderly, who represent the largest portion of the population that suffers immune dysfunction.1,7 Cytomegalovirus (CMV) is a chronic infection that, as you’ll discover later in this issue, may contribute significantly to degenerative disease. About 90% of older people showed history of CMV infection on lab testing compared to about 60% of the general population. 55 Increased prevalence of CMV in the elderly is thought to lead to decreased immune surveillance.56-61 "   How Immune Decline Hastens Aging

"Overlooked are studies showing vibrant NK function is crucial for the immune system to recognize and eliminate unhealthy/infected cells and dysfunctional (senile) cells.27,115 A pathologic consequence of too many senile cells is tissue/organ damage and chronic inflammation.116-119 Senile (senescent) cells reside in a state of irreversible cellular paralysis. Your body wants them to die and disappear, but they linger on for dangerously long periods. While these senile cells contribute nothing to healthy function, they remain metabolically active, secreting an array of dangerous growth factors and pro-inflammatory cytokines. Functional NK cells can eliminate senile cells before they buildup to lethal levels. When NK cells are hampered by aging, however, they are less able to remove deadly senile cells from our bodies. "   How Immune Decline Hastens Aging   Note this function of NK cells is VERY important for us old fogies.

As we grow older our NK cell response usually grows weaker and needs some looking after. If we fail to do this we will come down with "everything that is going around". This is no way to live and you need not do it. I have used IP6 for many years mostly as a phytic acid cleanse and HDL booster and am now using it in addition as a NK cell booster. I take plenty of Enzyme Modified Rice Bran. If you are over 60 or so and afraid of the seasonal flu or one of the man made bio weaponized viruses, you may want to look into a powerful innate system and NK Cell booster, Bovine interferon.

"These responses [Inducible Nonspecific Responses] including fever and release of class 1 interferons (alpha and beta) are activated when infectious agents manage to invade and they are particularly effective in preventing viral replication [Natural Killer Cell effectuators]"   Medical Immunology 5th Ed    Note Bovine Interferons (bio identical to human) can do this job; Kick your Innate Immune System, including NK Cell action, into action with fever and interferon.

      

Fighting Viruses and Natural Killer Cells

"The first line of defense against new invaders is our natural killer (NK) cells. NK cells come fully equipped to recognize any cells that don’t belong in your body.65 Such cells include those whose replicative machinery has been taken over by a virus, and also cells that have gone rogue to replicate without natural controls, such as cancer cells.16. As we age, NK cells lose their functionality, thus leaving us far more vulnerable to viral diseases—and the formation of tumors.9,10 Aging humans don’t have to succumb to this massive loss of NK cell function. Scientists have uncovered an enzymatically modified rice bran that has been shown to increase NK cell activity in circulating blood cells by up to 84%!11"   Activate Your Natural Killer Cells

"Natural killer cells (NK cells) are one of your body’s most powerful defenses against infections and cancer.13-15 These tiny security guards seek and destroy cells that have been transformed by an infection with a virus or by one of many malignant changes that transform them into cancer cells.9,16 NK cells work by triggering apoptosis (programmed cell death) in cells that have been transformed by a virus or malignancy.17,18 Without this critical defense mechanism, viruses can be spread throughout the body and cancer cells can form invading, metastasized tumors.9,19 The health of these cells is critical to a robust immune system. Unfortunately, your NK cell function rapidly declines as part of the natural decline in your immune system as you age.20-22 This degeneration of immune function is medically termed immune senescence."   Activate Your Natural Killer Cells

"Natural killer cells are the body’s first responders against viral infections and cancer cells, and play an important role in battling bacterial and fungal infections.19-24 The age-related decline in the function of natural killer cells leads to higher rates of many viral, bacterial, and fungal infections—and these infections are more likely to be serious in age-related immune senescence. For example, research shows that the common cold (which is caused by a virus) is more frequent in individuals with low numbers of natural killer cells—and conversely, that greater natural killer cell function helps protect against viral outbreaks. The decline in natural killer cells has also been shown to increase the rates of viral infections, including viruses that cause influenza and viruses in the herpes family.26 These include cytomegalovirus (CMV), Epstein-Barr virus, varicella zoster (which causes chicken pox and shingles), and herpes simplex viruses (causing oral and genital herpes). Compounding the problem, cytomegalovirus (CMV) itself may directly contribute to the loss of immune function.46,47 In one study, higher levels of CMV in older women correlated with an increased five-year risk of all-cause mortality."   Restore Youthful Immune Function

"The first line of defense against virus-infected28-31 and cancer cells is our natural killer cells.32-45 Young individuals have high levels of functional natural killer (NK) immune cells, but this declines with aging. 46-49 In elderly subjects, decreased NK cell activity is associated with an increased incidence and severity of viral infections such as shingles, influenza, and cytomegalovirus (CMV). 47,50-53 Natural killer cells originate in the bone marrow (like other immune cells) and go through a maturation process that enables them to participate in early control of microbial infections and cancers.47,62 "   How Immune Decline Hastens Aging

"When you were younger, your NK cells, which are part of your innate immune system, could destroy the new strain of virus while your adaptive immune system “learned” its properties and then made antibodies to destroy any remaining virus.30-33 But because your NK cell function declines with age, you can easily be rapidly overwhelmed by new viral strains before your slower adaptive immunity can develop. Similarly, older adults are at an increased risk of cancer because falling NK function fails to destroy malignant cells early on, allowing them time to develop various tricks that evade adaptive immunity while they grow into life-threatening tumors. Younger people have more robust NK function, which helps explain why cancers are generally so rare before late middle age. "   Activate Your Natural Killer Cells

"Shingles occurs when our immunity to dormant chickenpox viral infection declines. It manifests as an extremely painful skin lesion that can last for months. 54 Influenza, commonly called the flu, is a virus that inflicts its lethal effects mostly on the elderly, who represent the largest portion of the population that suffers immune dysfunction.1,7 Cytomegalovirus (CMV) is a chronic infection that, as you’ll discover later in this issue, may contribute significantly to degenerative disease. About 90% of older people showed history of CMV infection on lab testing compared to about 60% of the general population. 55 Increased prevalence of CMV in the elderly is thought to lead to decreased immune surveillance.56-61 "   How Immune Decline Hastens Aging

"These responses [Inducible Nonspecific Responses] including fever and release of class 1 interferons (alpha and beta) are activated when infectious agents manage to invade and they are particularly effective in preventing viral replication [Natural Killer Cell effectuators]"   Medical Immunology 5th Ed    Note Bovine Interferons (bio identical to human) can do this job; Kick your Innate Immune System, including NK Cell action, into action with fever and interferon.

Natural Killer cells are a critical part of your initial immune RESPONSE used to eliminate viruses from your body. The more robust your NK function the quicker you will be able to completely clear up any viral infection. A weak NK response and older age is a double whammy for us senior citizens. WATCH OUT grandpa.

      

Natural Killer Cell Enhancing

"Mainstream medicine has little to offer to counteract declining NK cell function. ... A better approach would be to change the way the body responds to threats like viruses and tumor cells by directly boosting NK cell function and restoring waning immunity caused by immune senescence.5,43 "   Activate Your Natural Killer Cells

"Cistanche plant extract stimulates development of naïve T cells and leads to a lower number of memory T cells, which creates a more balanced and healthier immune response. Cistanche also increases natural killer (NK)-cell activity (cells that seek and destroy cells infected with viruses or transformed by cancer)—an action that has been shown in animal research to result in lifespan increase. A human study found that individuals taking standardized Cistanche had impressive improvements in their immune profiles after 12 weeks. This included an 11.7% increase in natural killer cell activity and a 20.2% increase in the ratio of CD4 to CD8 cells, which is an indicator of healthier, more youthful immune function."   Winterize Your Immune Defenses

"Aging individuals are more vulnerable to viral (and other) diseases, in part because aging diminishes the functionality of natural killer (NK) cells. Scientists have uncovered an enzymatically modified rice bran that has been shown to increase NK-cell activity by up to 84%. Enzymatically modified rice bran is produced by exposing crude fiber from rice bran to enzymes isolated from the Japanese culinary mushroom shiitake (Lentinula edodes). In a four-month study conducted on individuals who were initially low in NK-cell activity, supplementation with one gram (1,000 mg) of enzymatically modified rice bran per day led to a four-fold increase in NK-cell activity at two months, compared to control responses. And at the end of four months, participants showed a seven-fold increase in NK cell activity. Consider adding 500 mg to 1000 mg daily during the wintertime virus season for added protection."   Winterize Your Immune Defenses

"IL-I2 [Interleukin 12] in conjunction with nitric oxide stimulates the cytotoxic activity of natural killer cells, enhancing their release of  ... [interferons], have also an important role in promoting Th1 lymphocyte differentiation."   Medical Immunology 5th Ed   Note without Nitric Oxide you have a difficult time jumpstarting your entire immune response; this lack of Nitric Oxide is one reason older people have weak immune systems; weak immune systems are the CHIEF reason older people Die. Beyond simply dying you WANT your last few decades of life to be Physically Productive; without NO this is not going to happen. So are some things more important than life itself? YES IMO.

If you consider that you must solve your CVD Problems AND your Arteriosclerosis Problems to assure optimal NO Production AND with your NO Problems solved your Life Expectancy SOARS. You can readily see why I consider your NO Problem perhaps your CHIEF Health Problem to solve.

 Image result for graph nitric oxide production and cardiovascular health

 

 

 

 

 

 

 

 

 

This File was last updated on 16 August 2020 07:53 AM

YOU are the ONLY one responsible for your life and health; others may be indirectly responsible for your death; once you realize this your life will get MUCH better and also in ways other than your health. Healthy Protocols is designed to help YOU PREVENT most disease in YOUR body. The Disease Prevention State is the beginning basis for all Disease Treatment. The information provided throughout this site should not be used during any medical emergency or for the diagnosis or treatment of any illness. Call 911 for all medical emergencies. A licensed integrative physician should be consulted for diagnosis and treatment of any and all illnesses you can not handle yourself (soon very few). You and your doctor should reach an informed consensus on diagnosis and treatment. It is incumbent on YOU to know enough about your illness to do this. Blindly following  some doctors orders will in the end sink you IMO. Links to other sites are provided for the targeted information indicated and links should not be regarded as an endorsement of all additional information that those other sites may provide although these sites are in general very good to excellent or I would not use them. Trust but verify. Trust government at your own risk. IMO toxic depopulation  politics is the cause of MANY of our health and our death problems. Trust yourself because YOU have become knowledgeable enough to trust.  All Rights Reserved © Healthy Protocols