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Polyphenol and Flavonoid Protocol

Polyphenols and Flavonoids are Stem Cell Promoting Agents

Polyphenols and Flavonoids are Members of the Vitamin C Complex

Polyphenols and Flavonoids are Highly Antioxidant

Polyphenols and Flavonoids are Effective Prevention and Treatment for many Diseases

Polyphenols and Flavonoids provide Athrosclerosis prevention

Polyphenols and Flavonoids provide for an Extended Health Span

        

Folks please do not ignore the copious and well documented evidence and GET a LOT of Super Salubrious Polyphenols/Flavonoids in your life. 

     

"Polyphenols also known as Polyhydroxyphenols, are a structural class of mainly natural, organic chemicals characterized by the presence of large multiples of phenol structural units. They may be broadly classified as phenolic acids, flavonoids, stilbenes, and lignans."   "Polyphenols: food sources and bioavailability". Am J Clin Nutr; 79: 727– , Note here we see flavonoids constitute many of the food based polyphenols

"Although it isn’t higher in absolute polyphenols, the larger serving size of cocoa makes it the biggest dietary source so far. cocoa contains a whole host of polyphenolic compounds which include flavonoid, phenolic acid, and other groups (24). Significantly, a wide range of research links the compounds in cocoa to protection against chronic diseases such as cardiovascular heart disease and dementia (25, 26)."   A Complete Guide To Polyphenols

  

Polyphenol classification. The classes of polyphenols include phenolic acids, flavonoids, stilbenes, and lignans. Examples of important subfamilies of each class are shown. 

  

Image result for polyphenols classification

Image Article Well worth reading   Note view the foods listed above and EAT THEM!

    

"Continuing research highlights the dynamic capacity of natural polyphenolic compounds to exhibit their antioxidant effect by a number of potential mechanisms. The free radical scavenging, in which the polyphenols can break the free radical chain reaction, as well as suppression of the free radical formation by regulation of enzyme activity or chelating metal ions involved in free radical production. Thus, the antioxidant properties certainly contribute to their neuroprotective effect. Polyphenols have gained much interest recently due to its antioxidant capacity and possible benefits to human health such as anti-carcinogenic, anti-atherogenic, anti-ulcer, antithrombotic, anti-inflammatory, immune modulating, anti-microbial, vasodilatory and analgesic effects."   Novel Function of Polyphenols in Human Health: A Review

"Polyphenols also known as Polyhydroxyphenols, are a structural class of mainly natural, organic chemicals characterized by the presence of large multiples of phenol structural units. They may be broadly classified as phenolic acids, flavonoids, stilbenes, and lignans."   "Polyphenols: food sources and bioavailability". Am J Clin Nutr; 79: 727– , Note here we see flavonoids constitute many of the food based polyphenols

"The class of polyphenols known as anthocyanins composed of deep red, blue and purple pigments possess powerful antioxidant properties. Fruits and vegetables of these colors blueberries, cranberries, pomegranates, black currents beets and acai are especially rich in anthocyanins. They are highly bioavailable and can significantly increase levels of other beneficial polyphenols in the blood. "  Life Extension

"Flavonoids are polyphenolic compounds that are ubiquitous in nature and are categorized, according to chemical structure, into flavonols, flavones, flavanones, isoflavones, catechins, anthocyanidins and chalcones. Over 4,000 flavonoids have been identified, many of which occur in fruits, vegetables and beverages (tea, coffee, beer, wine and fruit drinks). The flavonoids have aroused considerable interest recently because of their potential beneficial effects on human health-they have been reported to have antiviral, anti-allergic, antiplatelet, anti-inflammatory, antitumor and antioxidant activities."   Antioxidant Activities of Flavonoids

"Dr. Cimen Karasu is the head of the Department of Medical Informatics in the Faculty of Medicine at Gazi University in Turkey. She has authored more than a hundred papers appearing in peer-reviewed journals. Dr. Karasu's talk was largely a review of the damaging effects of free radicals and advanced glycation end-products (AGEs). She noted that flavonoids have been shown to increase the life span of nematode worms.21 She reviewed the benefits of a number of natural polyphenols, including quercetin and pomegranate extracts.22,23 She is starting a company in Turkey which will market a formulation based on olive leaf polyphenols.24,25 "

"Extensive research confirms that the most powerful antioxidant berries are those that contain a class of polyphenols known as anthocyanins. These nutrients create the deep red, blue, and purple pigments found in plants such as blueberries, elderberries, blackberries, and açaí. Berry anthocyanins strongly combat oxidative stress, a causative factor in the pathogenesis of many major diseases such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), cancer, and allergic disorders."   Uncovering the Broad-Spectrum Protection of Anthocyanins

"Polyphenols are chemicals that, by their intrinsic structure, diminish the effects of free radicals on surrounding tissues. The anthocyanin class of polyphenols is especially effective in blunting oxidative damage."   Life Extension

"Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans. Drugs Exp Clin Res. 2002. Pomegranate polyphenols were shown to reduce the capacity of macrophages to oxidatively modify LDL, due to their interaction with LDL to inhibit its oxidation by scavenging reactive oxygen species and reactive nitrogen species and also due to accumulation of polyphenols in arterial macrophages; hence, the inhibition of macrophage lipid peroxidation and the formation of lipid peroxide-rich macrophages. Furthermore, pomegranate polyphenols increase serum paraoxonase activity, resulting in the hydrolysis of lipid peroxides in oxidized lipoproteins and in atherosclerotic lesions. These antioxidative and antiatherogenic effects are demonstrated in vitro, as well as in vivo in humans and in atherosclerotic apolipoprotein E deficient mice. Dietary supplementation of polyphenol-rich pomegranate juice to atherosclerotic mice significantly inhibited the development of atherosclerotic lesions and this may be attributed to the protection of LDL against oxidation."   Ray Sahelian   Note the protection of our LDL from oxidation along with assuring sufficient vitamin C and collagen is the nut of Athrosclerosis protection

 "Apigenin is a polyphenol found in vegetables such as parsley and celery. It is receiving increased attention as a low-cost nutrient to protect against common cancers. What makes apigenin so fascinating is how it functions to starve cancer cells, promote cancer cell destruction, and protect cellular DNA against environmental toxins (that can result in future malignancies). Compounds such as indole-3-carbinol (I3C) are found in cruciferous vegetables. These cruciferous compounds have been shown to work in complementary ways with apigenin (non-cruciferous) to combat cancer and other age-related diseases. ... For example, apigenin fights excitotoxicity, the neuronal damage that occurs over a lifetime of intense brain cell stimulation.3,6 This is critical since excitotoxicity promotes brain cell death and dysfunction in both Alzheimer’s and Parkinson’s diseases."   Vegetable Ingredients Protect Against Cancer

"Cocoa is so full of polyphenols that they practically spill out of the container. This study is not a license to go out and eat chocolate bars and chocolate candy. Instead, buy some plain old pure unsweetened cocoa powder – you'll find it in just about any supermarket, usually in the baking aisle – and add it to your coffee.”   Doctor William Douglass MD

Polyphenols are a plant nutrient superset that contains the flavonoids, anthocyanins. lignans and others. Note the stilbenes group of polyphenols is largely represented by resveratrol; get this polyphenol into your life. The lignans by volume are mainly included in FLAX as FLAX contains 100 times more lignans than the next lignan source. Eating some freshly ground flax seeds EVERYDAY is a great polyphenol habit.

Living without being aware of the COPIOUS benefits of Polyphenols/flavonoids is putting yourself at a HUGE disadvantage in life.

    

Polyphenols for Super Health

"New studies reveal that the high content of polyphenols found in the foods that comprise the Mediterranean diet is a key factor in its ability to reduce the risk of dying. The beneficial impact of a healthy diet on human physiology remains grossly underappreciated. Virtually every degenerative disease can be favorably influenced by dietary intervention. Yet modern medicine relies almost exclusively on prescription drugs to treat chronic illnesses."   Newly Discovered Longevity Benefits of Mediterranean Diet

"Plant polyphenols are complex biological molecules produced by natural processes. More than 8,000 different polyphenol compounds have been identified in plants, with several hundred readily available in edible plants. While best known for their ability to fight and protect against oxidative stress, polyphenols have numerous other properties. These include anti-inflammatory, anticarcinogenic, antidiabetic, antiobesity, and anti-allergic properties, along with liver and stomach protective effects. Epidemiological studies compellingly demonstrate the clinical impact of these mechanisms in preventing cardiovascular and neurodegenerative diseases, as well as certain cancers."   Newly Discovered Longevity Benefits of Mediterranean Diet

"In addition, subjects with the greatest rise in polyphenol levels had significantly lower systolic and diastolic blood pressure, and significantly increased levels of beneficial HDL cholesterol, compared with those with the lowest polyphenol elevations. It is clear from these studies that the polyphenols in the Mediterranean diet account for a large proportion of its value in preventing catastrophic heart disease, stroke, and cardiovascular deaths."   Discovered Longevity Benefits of Mediterranean Diet   Note if you examine the components of the Mediterranean Diet you will find many of many KEY polyphenols, flax comes immediately to my mind

"Abundant research continues to reveal the longevity benefits of the Mediterranean diet. But we never knew the main factor behind the diet’s remarkable effects…until now. Research has revealed that the polyphenols (a plant-based compound) found in the Mediterranean diet may be responsible for its ability to reduce mortality risk. This is the diet’s prime weapon driving its capacity to lower risks of heart attack, stroke, high blood pressure, and inflammatory markers."   The Secret Behind the Mediterranean Diet’s Benefits

“Nigella sativa's common name is black cumin seed. Historians tell us people have used this seed for medical purposes as far back as the time of King Tutankhamen in Egypt. And now we know why. Black cumin seed is a potent source of phytochemicals. So powerful that researchers found it reduces both systolic and diastolic blood pressure. What's more, it also reduces total and LDL cholesterol as well.”   Doctor Robert Rowen MD     Note WOW what a combo

Image result for polyphenols

Natural News: An individual can expect to see polyphenols improve their health in these six ways

 At base polyphenols are found in FOODS that supply many important nutrients, There are over 8000 types of polyphenols we have discovered. We know many of the most important and the FOODS they are found in; please EAT them,   

           

Stem Cells and Polyphenols  

Recent scientific findings indicate that aging is closely associated with a loss of the number and function of adult stem cells throughout the body. Researchers have concluded that protecting those essential stem cells could play an important role in slowing and partially reversing aging. Three studies published last year demonstrate that several nutraceutical compounds are capable of boosting stem cell function. These studies revealed that extracts [polyphenols] from berries and green tea, the dipeptide carnosine, and vitamin D—have the ability to favorably alter gene expression, and are capable of exerting powerful regulatory effects on stem cells and their environment. These findings should help to crystalize the importance of utilizing natural molecules as a means of slowing aging."   Nutrients Boost Stem Cell Function

As you see above polyphenols can help with stem cell expression and operation a very desirable effect of the powerful polyphenols. As you grow older, say above 40 or so, you had better get to know and learn how to take care and feed your stem cells; these stem cells will be replacing your worn out body OR NOT; largely depending on YOUR ACTIONS.

     

Skin and Polyphenols  

"One of the key properties of polyphenols in general is their exceptional antioxidant properties. They are fantastic scavengers of reactive oxygen species that are generated in our tissues when exposed to harmful UV rays from the sun and lead to various skin disorders, including in the extreme, skin cancer. There are a multitude of other benefits as well as shown in the picture below:"   Extracting the good stuff from plants

Picture

Here and in the Skin Protocol we see some ways to protect against UV radiation without harmful chemicals. Our friends the polyphenols play an important part.

     

Some KEY Polyphenols

Image result for polyphenols

However you do it get a LOT of the the KEY Polyphenolic foods and supplements

      

Cocoa, Coffee, Lentils, Flax Seed, and Cherry  are Dirt Cheap powerful sources of Polyphenols

"Although it isn’t higher in absolute polyphenols, the larger serving size of cocoa makes it the biggest dietary source so far. cocoa contains a whole host of polyphenolic compounds which include flavonoid, phenolic acid, and other groups (24). Significantly, a wide range of research links the compounds in cocoa to protection against chronic diseases such as cardiovascular heart disease and dementia (25, 26)."   A Complete Guide To Polyphenols

"Polyphenol compounds (sources and general health benefits of polyphenols)
Sources of polyphenols: Cranberry, apple, red grape, strawberry, pineapple, banana, peach, lemon, orange, pea grape fruit, broccoli, spinach, yellow onion, red pepper, carrot, cabbage, potato, lettuce, celery, cucumber, aloe, fennel, basil, ginger, pomegranate, red chili, tea, red grapes and others."   Novel Function of Polyphenols in Human Health: A Review

"A New England Journal of Medicine paper showed that the Mediterranean diet can reduce the risk of cardiovascular events—including death—by 30%. This was not an epidemiologic study showing simple correlation, but instead was a true intervention study, from which one can conclude that the diet produced the observed health benefits. Follow-up studies showed that a large part of the cardiovascular protective effect of the Mediterranean diet comes from its high concentration of polyphenols."   Discovered Longevity Benefits of Mediterranean Diet

"For example, one of these phenols, resulting from the breakdown of polyphenols in the colon, travels to the liver. There it can act on various bone-marrow progenitor cells that circulate to tissues throughout the body, where they signal for new cell and tissue generation, particularly turning on bone-cell lines and turning off fat-cell lines. This body-wide bioactivity explains a compelling study conducted on 807 men and women aged 65 and over that was published in The Journal of Nutrition. Those in the highest third of total urinary polyphenols (which reflect circulating levels of polyphenols in the blood) had a 30% lower all-cause mortality over the 12-year follow up, compared with those in the lowest third."   The Secret Behind the Mediterranean Diet’s Benefits   Note here we see how phenols can get your stem cells activated. A very good thing.

       

A Complete Guide To Polyphenols (and 100 Foods High In Them)

     

  • Spices  

    "Want to Know the Real Secret to Beating Disease? Its a diet rich in whole foods such as fruit and vegetables - and rich in spices. In fact worldwide scientific research has linked spices to the prevention and treatment of more than 150 health problems, including heart disease, cancer, type 2 diabetes and Alzheimer's. Spices are so powerful because they're super - rich sources of plant compounds that fight oxidation and inflammation, the two processes underlying most clinical disease."   Healing Spices

    "Cocoa, the spice, is one of the richest sources of flavanols, plant compounds that help protect the heart in a variety of ways. Study after study shows that cocoa flavanols can disarm cell damaging free radicals. preserve cell membranes. protect DNA., prevent the formation of artery clogging plaque, improve blood flow to the heart. lower high blood pressure and prevent blood clots that can cause a heart attack or stroke."   Healing Spices   Note WOW

    Spices comprise most of the top high phenolic herbs and foods.

    Cloves and cinnamon emerged as the leading spices in phenolic content among the extracts tested. Phenols are plant compounds which have an antioxidant and other salubrious properties. Other spices score very high in ORAC scores.

          

  • Cloves (15,188 mg per 100g)  Note this is 15% Polyphenols

    "The spice with the highest rated ORAC value, and the deemed the most beneficial of the herbs tested in the study just mentioned, is cloves. Cloves contain eugenol, which has mild anesthetic and anti-bacterial and anti-inflammatory properties, making it useful for toothaches and sore throats, in addition to their ability to prevent more serious problems such as heart disease."   Doctor Joseph Mercola ND

    "All those therapeutic powers help explain why eugenol (clove) is not only a home remedy for an untreated toothache but a formidable medicine against many forms of oral disease. It can fight gingivitis the early stage of gum disease, when gums are inflamed. It fan fight periodontitis, the later stage, when gums recede and bone erodes. Its also effective against stomatitis a painful inflammation of the mucous ling of the mouth, caused by factors such as medications poor dental hygiene or ill-fitting dentures."   Healing Spices  Note be sure to hold in your mouth, soften and chew a few cloves from time to time or daily as I do. You are PREVENTING a whole raft of potential dental, oral and upper respiratory problems

    I make sure to eat about a half dozen whole cloves/day. I wonder why? LOL I put cloves in any drink I may have and LOTS of cloves in a cocoa drink; when done drinking I eat the softened cloves.

     

  • Cinnamon 

    “Cinnamon lowers your blood sugar by acting on several different levels. It slows the emptying of your stomach to reduce sharp rises in blood sugar following meals, and improves the effectiveness, or sensitivity, of insulin. It also enhances your antioxidant defenses. A study published last year stated that "polyphenols from cinnamon could be of special interest in people that are overweight with impaired fasting glucose since they might act both as insulin sensitizers and antioxidants. Yet another bioflavonoid compound called proanthocyanidin may alter the activity of insulin signaling in your fat cells.”     Doctor Joseph Mercola MD  

    "One of the most stubborn aspects of normal aging is accumulation of deep visceral (abdominal) fat. Not only can this be unsightly, but it generates systemic inflammation and glucose/lipid imbalances that are root causes of metabolic syndrome and type II diabetes. Seeking a natural approach to boosting AMPK, researchers studied a citrus flavonoid called hesperidin. Laboratory results show that hesperidin markedly activates AMPK."  Reverse Underlying Cause of Degenerative Aging  

    Cloves and cinnamon emerged as the leading spices in phenolic content among the extracts tested. Phenols are plant compounds which have an antioxidant property. Other spices score very high in ORAC scores.

    I make sure to eat at least a half teaspoon of cinnamon most days.

         

  • Celery Seed (2,094 mg per 100g)

    “A recent study has shown celery to kill up to 86% of human lung cancer cells (NCI-H460) in vitro, by inducing programmed cell death (apoptosis). Apigenin is well known as a powerful anti-cancer compound and has been shown in other studies to kill many other types of cancer including breast, prostate, pancreatic and ovarian cancers. Two recent studies have shown that women eating diets high in apigenin reduced their risk of ovarian cancer by 20%, and reduced their risk of breast cancer risk by 19%. What is promising is a study from China found that people eating 2 to 3 servings of celery per week reduced their risk of lung cancer by an astonishing 60%.”   Celery Found To Kill 86% Of Lung Cancer Cells In Vitro

    "In an exciting new discovery, scientists have uncovered two natural extracts that have similar mechanisms to some of the most effective drug therapies for hypertension. Olive leaf extract has been shown to function as an ACE inhibitor and celery seed extract has potent calcium channel blocking properties.6,7 Clinical studies have demonstrated that both extracts are able to safely lower blood pressure.8,9 These specialized extracts offer a natural approach to blood pressure management."   Natural Extracts Lower Blood Pressure

    I started taking celery seed daily as a prophylactic/treatment for my gout some 60 years ago; it worked. What good fortune; as the years went by I discovered celery seed is one of the very best foods, supplements and condiments you can eat. I buy celery seed by the 5 pound lots several times a year and eat some with almost every meal; several times a day.

         

  • Dried Peppermint (11,960 mg per 100g)

    "Peppermint is actually a hybrid of spearmint and watermint. This popular herb is popular throughout the world, and it contains scores of phenolic acids, flavones, and flavanones (22). People enjoy peppermint in all kind of ways, and we can find its strong flavor in everything from chewing gum to herbal tea."   A Complete Guide To Polyphenols

    "Some people seek an alternative to coffee for a quick boost in levels of attention, concentration, and focus. The good news is that scientists have shown in human studies that the phenolic compounds in spearmint enhance performance on tests of working memory, focus, attention, and concentration—while allowing volunteers to get to sleep faster at night. Preliminary lab data show that spearmint polyphenols may promote the growth of new brain neurons, protect existing neurons, and boost levels of neurotransmitters. Instant spearmint herbal tea is available in one-cup, grab-and-go packets that provide a high concentration of phenolic compounds, especially potent rosmarinic acid—providing an ideal, caffeine-free way to improve mental focus."   Spearmint Tea Quickly Boosts Mental Focus

    "As an added benefit, those in the spearmint group reported improvement in the time it took to fall asleep—and on awakening, they were more alert. Improved mood was also observed by using a standard psychological-rating scale. These treatment effects alone could make a big difference in how well we are able to function on any given day Together, these studies make it clear that this novel spearmint extract significantly helps aging individuals to stay focused and on-task, through both enhanced cognition and working memory—and via improved sleep. As the author of the recent clinical study wrote, spearmint “may be a beneficial nutritional intervention for cognitive health in older subjects with age-associated mental impairment."   Spearmint Tea Quickly Boosts Mental Focus

    You can get a simple dried spearmint supplement or any mint; do it and use it every day IMO; also grab and use any fresh mint your are able to grow or get. This high phenolic mint is not to be missed.

         

  • Black Olives (569 mg per 100g)

    “In the early 1960s the Corsican people had a diet composed of 47% fat but since most of the fat was healthy fat, most of it Olive Oil, the Corsicans were healthy and mostly slim.”  

    “Since saturated fats (from animal foods and the tropical oils) and monounsaturated oils (from olive oil and cold-pressed nut oils) are more chemically stable, they are much less susceptible to oxidation and rancidity than their polyunsaturated cousins, which are mostly found in vegetable oils. As a general rule, then, although the body does require a small amount of naturally occurring polyunsaturated oils in the diet each day, it's best not to consume too much of them as they are more prone to free radical attack in the body. As Linus Pauling, PhD noted: "A diet high in unsaturated fatty acids, especially the polyunsaturated ones, can destroy the body's supply of vitamin E and cause muscular lesions, brain lesions, and degeneration of blood vessels.” Care must be taken not to include a large amount of polyunsaturated oil in the diet” Stephen Byrnes

     “People who consume higher amounts of vegetable oils (corn oil, soybean oil, safflower oil, etc.) lose their vision 3.8 times faster, and have twice the risk of macular degeneration.” Doctor Paul Beaumont

    Eat olives and olive oil folks; avoid the toxic man-made processed vegetable oils.

       

  • Plum (377 mg per 100g)   

    Plums appear on many lists of high Polyphenol foods.

         

  • 100% Cocoa Powder   (3.448 mg per 100g)

    "Cocoa is so full of polyphenols that they practically spill out of the container. This study is not a license to go out and eat chocolate bars and chocolate candy. Instead, buy some plain old pure unsweetened cocoa powder – you'll find it in just about any supermarket, usually in the baking aisle – and add it to your coffee.”   Doctor William Douglass MD

    "Cocoa flavanols improve endothelial function by enhancing nitric oxide bioactivity,36 increasing blood flow,36 reducing the tendency of blood to clot,37 promoting already normal blood pressure levels,38 and helping LDL resist oxidation, which may contribute to the buildup of atherosclerotic plaque in artery walls.39 In a controlled human study, six weeks of cocoa consumption increased brachial artery hyperemic blood flow by up to 76% compared with baseline values.40 In a recent randomized controlled trial, healthy individuals with above-optimal blood pressure took small amounts of dark chocolate containing 30 mg of polyphenols as part of a usual diet. The cocoa polyphenols in the chocolate efficiently improved their blood pressure readings as well as plasma markers of vasodilative nitric oxide.41 The age-related depletion of nitric oxide is considered a major impediment to healthy arterial blood flow."      Life Extension   Note will not feed your pet LOL

    "Although it isn’t higher in absolute polyphenols, the larger serving size of cocoa makes it the biggest dietary source so far. cocoa contains a whole host of polyphenolic compounds which include flavonoid, phenolic acid, and other groups (24). Significantly, a wide range of research links the compounds in cocoa to protection against chronic diseases such as cardiovascular heart disease and dementia (25, 26)."   A Complete Guide To Polyphenols

    Cocoa is often singled our in the antioxidant and food nutrient sources papers I read as a SUPERB nutrient. Each day I consume at least two or more ounces of 100% cocoa powder. It will be by far often your most abundant source of polyphenols.

       

  • Coffee

    "If I told you there was a drink that might reduce the risk of diabetes, Parkinson's, cirrhosis, gallstones and liver cancer, you might be surprised to find it in Starbucks. But coffee is such a significant source of antioxidants that it could feasibly claim to be a health beverage."   Life Extension,  Just remember the sugar and oxidized milk in your average cup of coffee can negate a lot of the benefits of the coffee bean Polyphenols IMO

    Yes folks now I know why coffee is the PRIME antioxidant source for most Americans. Just remember it is the Phenolic Acids in coffee that contain the nutrients. All the sugar, HFCS, milk, caffeine et al are ingredients in a cup of coffee that DETRACT from your health.

    Figure out a way to improve the phenolic content of your coffee while at the same time flavoring it. How about adding cocoa and perhaps a little cinnamon or peppermint and some cloves?

    Please BREAK your habitual SUGAR indulgence; yes it takes a little time to do this. Once you do a whole new world of FLAVORS will open up to you; not to mention much better health. NO SUGAR in your coffee or tea is a GREAT heath habit to start and STAY with through a long healthy life. Trust me after a month or two you will thank me.

         

  • Grape Seed Extract and Resveratrol

    "Grape seed extracts are loaded with polyphenols, and numerous studies have testified to their ability to protect heart health on multiple levels."

    "Just recently, Life Extension reported that experimental animal studies conducted by BioMarker Pharmaceuticals were under way using the same grape extract fortified with resveratrol that is currently used by Foundation members.6  ... These findings paved the way for further analysis identifying the specific molecular pathways involved in these effects. Here we provide an update to these earlier findings."   What Dose of Resveratrol Should Humans Take?

    “While grape polyphenols’ primary mechanism appears to be that of reducing low-density lipoprotein oxidation via their antioxidant property, the compounds also decrease blood clotting, improve abnormal heart rhythms and help reduce narrowing of the blood vessels, possibly through effects on cellular signaling and gene activity.”    Leifert et al 2008

    "After searching for natural, deep vein thrombosis-inhibiting interventions, scientists identified two ingredients that demonstrated powerful preventive effects: Nattokinase, an enzyme extracted from soybeans fermented with the bacterium Bacillus natto, and French maritime pine bark, a natural extract rich in polyphenols. ... Nattokinase and pine bark extract were shown to work together to prevent clots as well as to improve the microcirculation of the legs."   Natural Approach to Guard Against DVT Note GSE can be used in place of French maritime pine bark

    Grape Seed Extract is the poor mans Resveratrol®.  Resveratrol® is a propriety form of OPC. However Resveratrol’s® bioflavonoid concentration is 85% while that of grape seeds' often is higher. Both grape seed extract and resveratrol® contain the flavonoid OPC.

    I take GSE every day, often several times.

         

  • Cherry  

    "When they tested a variety of fruits for six specific anthocyanins (including cyanidin and peonidin), they found that apples contained one, strawberries contained two, and grapes contained three—but only tart cherries contained all six key anthocyanins.4 When they further tested these and other anthocyanin-rich fruits for three key flavonols (such as quercetin and kaempferol), once again, tart cherries were the only fruits found to contain all three flavonols.4 Similarly, when they tested several anthocyanin-rich fruits for nine other potent natural compounds including polyphenols, tart cherries were the only fruit shown to contain all nine.4 "   Broad-Spectrum Disease-Fighting Properties of Tart Cherries

    “What can’t cherry suppliers tell you? Simply this: tart cherries may well be the ultimate super food. Due to their superior phenolic matrix, tart cherry compounds help reduce the risk of osteoarthritis, gout, obesity, cardiovascular disease, metabolic syndrome, diabetes, and neurodegenerative diseases such as Parkinson’s and Alzheimer’s. And Life Extension® will continue to report the latest scientific findings about tart cherries and their potent health benefits!”   Anti-Inflammatory Properties of Tart Cherry   Note Folks how much longer do we put up with these FDA criminals?

    Don't miss this very tasty fruit packed with polyphenols; also good for gout and the over one hundred types of arthritis.

     

  • Olive Leaf Extract  

    "Olives are perhaps one of the most central components of the typical Mediterranean diet. Polyphenol extracts from the olive leaf have been shown to potently protect cultured heart muscle cells from destruction caused by an intense oxidant chemical challenge.38 They also decrease tissue damage by such oxidative stress, while boosting intracellular resistance systems."

    OLE is one of my prime go to supplements to fight all persistent episodic flu like disease symptoms. Most of the time you are fighting an unknown virus, bacterial or other pathogen. It does not matter the OLE and several other of these polyphenols help knock em out in a day or two.

         

  • Pomegranate Peel Extract  

    "Pomegranates are known to be one of the healthiest fruits on earth. Extracts from pomegranate peel have a variety of anti-inflammatory effects that are especially beneficial for people at risk for cardiovascular disease."

    "Pomegranate flavonoids were equal to green tea and even better than red wine when it came to preventing oxidation of LDL ... they also found straight pomegranate juice to be more potent than red wine. ... Drinking sparkling sweet-tart pomegranate juice for daily two weeks increased production of an enzyme that can protect against cancerous changes in cells."   New Healing Foods

    “Several studies have shown that pomegranate has antioxidant and anti-atherosclerotic properties attributed to the presence of multiple polyphenols such as tannins, flavonols, anthocyanins and ellagic acid (1) (2). Pomegranate juice has been shown to suppress inflammatory cell signaling (1), inhibit prostate tumor growth and lower serum PSA levels (3) (4), and also inhibit aromatase activity, endogenous estrogen biosynthesis and breast cancer cell proliferation (5) in vitro. Consumption of pomegranate juice was found to benefit patients with carotid artery stenosis (6), in those with hypertension (7), and in patients with coronary heart disease (CHD)(8).” Memorial Sloan-Kettering Cancer Center

    Each year I wait for the pomegranate season to feast on this wonderful fruit. Off season I use the supplements. Make sure to eat as much as the white and red peel as  you are able. Yeah it takes a little mensch.

            

  • Green/Black Tea Extract

    "Green tea protects against many age-accelerating factors, particularly DNA damage, while also promoting DNA repair. These systems work with extreme precision to identify, remove, and heal damaged DNA.3,4 A recent analysis showed that green tea polyphenols have 200 human target genes, including those involved in inflammation, cancer, diabetes, neurodegenerative, muscular, and cardiovascular disease.5 In addition, green tea supplementation has been found to significantly reduce the risk of diabetes, stroke, and depression and improve blood levels of cholesterol and glucose.6 "   Green Tea

    "Data from this March 2017 analysis found a dose-associated reduction of prostate cancer risk in men who drank green tea. The more green tea men drank, the lower their prostate cancer risk based on linear analysis. When this study evaluated green tea polyphenol (catechin) intake, there was an associated 62% reduction in prostate cancer risk based upon three randomized controlled human trials."   Green Tea and Prostate Cancer

    "Besides its ability to improve circulation, it can help stabilize blood sugar and combat underlying causes of cancer. But it’s not just that green tea is healthy—it can reduce your risk of dying! A decade of meticulous research evaluated hundreds of thousands of people in relationship to their dietary habits. The results showed that the higher the consumption of green tea and its polyphenol constituents, the lower the overall risk of dying from any cause. This longevity benefit is especially pronounced in older populations. Green tea combats many underlying processes that contribute to premature aging and disease. Here, we’ll evaluate compelling studies showing that green tea reduces all-cause mortality. Then we’ll look at how green tea or its components help reduce the impact of specific health problems that contribute to premature death."   Green Tea Reduces Mortality

    Green/Black tea is loaded with polyphenols. I take a green tea extract supplement most days in the morning.

         

  • Flax Seed  (1,528 mg per 100g)

    “Wherever flaxseeds become a regular food item among the people, there will be better health.”  Mahatma Gandhi 

    "Doctor Budwig cured cancer, not treated but cured, in terminally ill patients whom the cancer establishment declared hopeless. Her cure rate was over 90% including all the “terminal” cases. Doctor Budwig’s simple formula consists of good fats, sulfur rich proteins and omega 3 rich freshly ground flax."    The Cancer Report , Note Doctor Budwig's ground flax may have a hidden kicker. Flax is also rich in vitamin B17 which is strongly anti-cancer.

    "Research has shown that people who consume a high intake of lignans in their diet have markedly lower cancer rates. Lignans not only have anti-cancer properties, they have anti-viral, anti-bacterial, and anti-fungal properties. Flax hulls contain potent nutrients that have the potential to enhance immune system functioning and are effective against many different diseases (such as colon cancer , breast cancer, diabetes, lupus, prostate cancer, etc.)."   Flax Hull Lignan Anti-Cancer Studies

    Flax is the only great way to get your required Polyphenol Lignans.

    Flax is one of the few plant sourced ways to get your required Omega EFAs, especially the critical Omega 3 IMO AND the anti-cancer critical Vitamin B17 and Flax Lignans; you should ingest freshly ground flax three times a week or more often IMO.

    Flax seed has 100 times the Polyphenol lignans as the next highest source. Get the WHOLE seed and grind it on demand as the oil quickly goes rancid. All the lignans are contained in the flax MEAL. Here is a dirt cheap source of polyphenols, including the hard to get Lignans.

       

  • Quercetin

    "Quercetin, another polyphenol found in red wine and many other plant sources, also upregulates PON-1 gene expression, protecting against LDL oxidation.47 Quercetin also possesses numerous mechanisms of action Like pomegranate ,it helps stabilize and preserve PON-1 activity against oxidative stress.48."    Slow-and-Reverse-Atherosclerosis

    "An article published on September 2, 2014, in the journal Antioxidants and Redox Signaling provides evidence that beneficial compounds from broccoli, onions, and other foods could boost cellular defense.* The current study centers on Nrf2, a protein that enters and exits the cells’ nuclei once every 129 minutes, according to research first conducted by Professor Paul J. Thornalley, of England’s University of Warwick, and associates. When the protein is exposed to health threats, the rate of oscillation and cellular defense increases. Dr. Thornalley’s team found that sulforaphane, found in broccoli and other cruciferous vegetables, and quercetin, from onions, apples, and other plant foods, increase Nrf2’s speed of oscillation between the cell’s nucleus and cytoplasm to once every 80 minutes."    Antiox Redox Signal. 2014 Sep 2 

    What to Take with your Quercetin

    Quercetin, rutin and hesperidin can be taken together with vitamin C for better results. The absorption of quercetin is limited, and studies have shown that the enzyme bromelain is capable of increasing the intestinal absorption of quercetin. Quercetin appears to potentiate and adjuvanticate resveratrol so IMO take it with resveratrol and grape seed extract often.

       

  • Rutin

    "Three of the better-known bioflavonoids, quercetin, hesperidin, and rutin, have intriguing research indicating their abilities to prevent and reverse wrinkles, reduce the appearance of age spots, and fight spider veins. As potent as these plant metabolites are on their own, they exhibit an even greater effect when they're  used  together, as studies have shown they work synergistically by harmonizing with each other 20,21."   How Bioflavonoids Create Youthful Skin Tone

    "Vitamin C used to treat scurvy and other deficiency conditions is more effective when given as a natural food concentrate which includes minerals, rutin and other analogs."   Sally Fallon

    Rutin part of the Vitamin C Complex Components is a bioflavonoid antioxidant, anti-inflammatory that has anti-CVD and anti-carcinogenic properties. Rutin helps to keep your arteries and veins elastic. Rutin helps the body utilize  and recycle vitamin C and maintain collagen.

       

  • Hesperidin 

    "Three of the better-known bioflavonoids, quercetin, hesperidin, and rutin, have intriguing research indicating their abilities to prevent and reverse wrinkles, reduce the appearance of age spots, and fight spider veins.3-6. As potent as these plant metabolites are on their own, they exhibit an even greater effect when they're  used  together, as studies have shown they work synergistically by harmonizing with each other 20,21."   How Bioflavonoids Create Youthful Skin Tone

    "Oranges are one of the most popular fruits in the U.S., but very few consume the [Orange] peel, which is arguably the healthiest part of the whole fruit. Orange peels are rich in flavonoids, like hesperidin and polymethoxyflavones (PMFs), and other phytochemicals, which contribute many of their health benefits. Flavonoids antioxidant compounds found in certain fruits, vegetables, herbs, and spices — are known for their role in helping to prevent chronic diseases like heart disease and cancer. In addition, orange peel contains higher amounts of certain nutrients than its flesh. For instance, 3.5 ounces of orange peel provides 136 milligrams (mg) of vitamin C, while the flesh contains about 71 mg. Orange peel also contains considerable amounts of calcium, copper, magnesium, vitamin A, folate and other B vitamins and dietary fiber."    Doctor Mercola ND   Note this is explosive EAT those orange PEELS!

         

    Eat the WHOLE Orange, Especially the PEEL  to get the Hesperidin and hundreds of other nutrients not found in the flesh

    Note if you make a slurry by blending the complete orange; drink ALL of the somewhat bitter slurry; discard NOTHING; add some water to make a less thick slurry. You will quickly appreciate the somewhat different taste.

    It is important to remember that vitamin C is a COMPLEX of substances. Hesperidin is one of those components. This explains hesperidins' many salubrious properties in relation to collagen. To fully enjoy hesperidins' many benefits you MUST assure you also get ALL the other vitamin C components.

    Rutin, Quercetin  and Hesperidin, all components of the Vitamin C complex, SHOULD be taken together for best results. I take Rutin, Quercetin and Hesperidin daily with my Vitamin C complex.

         

  • Bilberry

    "The class of polyphenols known as anthocyanins composed of deep red, blue and purple pigments possess powerful antioxidant properties. Fruits and vegetables of these colors blueberries, cranberries, pomegranates, black currents beets and acai are especially rich in anthocyanins. They are highly bioavailable and can significantly increase levels of other beneficial polyphenols in the blood."     Life Extension

    Bilberry  

    "Bilberry, a relative of the blueberry, promotes frontline prevention against cardiovascular disease by significantly inhibiting angiotensin-converting enzyme (ACE), which contributes to hypertension by promoting narrowing of the arteries (vasoconstriction). Bilberries improve insulin sensitivity, which may help ward off diabetes. They also enhance short-term memory in animal models, suggesting the potential to help prevent Alzheimer’s disease."   Uncovering the Broad-Spectrum Protection of Anthocyanins

    Bilberry is a Flavonoid rich berry similar to the blueberry (See Blueberry Protocol) with anti-oxidant, and anti-inflammatory  properties. Bilberry has demonstrated benefits for the eyes, digestive and circulatory systems. Bilberries strengthen your blood vessels keeping them from leaking. Bilberries have been shown to be a potent tool against CVD, dementia, cancer as they apply their antioxidant and other protections throughout your body.

       

  • Pecans  

    "Pecans have been associated with reductions in cardiovascular disease risk. This is in part because they play an important role in reducing LDL cholesterol.41 Research also shows that they boost plasma antioxidant capacity in the critical after-meal period, which helps to decrease the dangerous oxidation of LDL cholesterol that leads to atherosclerosis."

    Nuts and seeds are the most nutritionally dense foods you can eat. If you can reduce the oxidation of your LDL and increase your HDL you VASTLY reduce your risk of CVD.

         

  • Walnuts  

    "Walnuts are one of the most important food sources of polyphenols.47 Extracts from these flavorful nuts have been found to inhibit LDL oxidation in human plasma, an action that reduces the amount of this highly inflammatory compound.48 Walnuts also induced a 55% reduction in plaque development in the aorta of supplemented mice, while also lowering plasma triglycerides by 36%, cholesterol by 23%, and prothrombin (an enhancer of blood clot formation) by 21%, compared to controls."   A Complete Guide To Polyphenols

    "The functional importance of the PPO-activity in walnut hull was first described in 1991 (). Walnut PPO was attributed to possess a putative pathogenic resistance as early as 1911 (). Walnut leaves have a high content of various polyphenols, some of which might be important in pathogenic resistance (). PPO from walnut leaves has been poorly studied in the past (). demonstrated that PPO of walnut is encoded by a single gene, jrPPO1, which is constitutively expressed in all green, herbaceous tissues of walnut."   Purification and characterization of tyrosinase from walnut leaves

    Nuts and seeds are the most nutritionally dense foods you can eat. If you can reduce the oxidation of your LDL and increase your HDL you VASTLY reduce your risk of CVD.

         

  • Lentils  

    "Lentils comprise a large part of the Mediterranean diet and are a good source of fiber, B vitamins—and, of course, polyphenols. Extracts made from lentils have been found to prevent high blood pressure induced by the hormone angiotensin-II, a vessel-constricting signaling molecule. This action helps protect against arterial narrowing."   Note here is a DIRT Cheap polyphenol, if you cook the lentils just a little it will slow their digestion and not bring on the carb rapid sugar release syndrome. Lentils have become my go to carb.

    Polyphenols are a hot nutrient these days and many supplements and foods that contain polyphenols are expensive. A 25 pound sack of lentils costs about 20 bucks; in terms of polyphenols the bargain of a life time which I purchase often.

    Dirt cheap Lentils can serve as a replacement for pasta; try it. Find a way to get this dirt cheap polyphenol source into your life. Notice most of the other polyphenols in this list are much more expensive than the common lentil. Eat this inexpensive polyphenol.

         

  • Black Cumin Seed  

    “Nigella sativa's common name is black cumin seed. Historians tell us people have used this seed for medical purposes as far back as the time of King Tutankhamen in Egypt. And now we know why. Black cumin seed is a potent source of phytochemicals. So powerful that researchers found it reduces both systolic and diastolic blood pressure. What's more, it also reduces total and LDL cholesterol as well.”   Doctor Robert Rowen MD   Note WOW what a combo

    Another inexpensive source of powerful polyphenols.

           

  • Artichoke Extract  

    "Artichokes are a staple of the Mediterranean diet. Artichoke extracts (made from the leaf, stem, and root of artichokes) have been found to have numerous cardioprotective effects. For example, they have been shown to inhibit cholesterol synthesis and LDL oxidation." 

  • "Some of the star players, when it comes to antioxidants, are the polyphenols, which have chemopreventive properties, meaning they can stop, slow and even reverse cancer. One study showed that properties in artichoke can cause programmed cell death in cancer cells, called apoptosis, halt the formation of new cancer cells and in breast cancer cells, may inhibit their ability to divide without harming normal cells.15 Further: “Artichoke leaf extract also has antitumor effects in mesothelioma (a type of cancer caused by asbestos in tissues that line the lungs, stomach or heart) cancer cells. It reduced cell growth and migration."   Health Benefits of Artichokes

    Artichoke is LOADED with Polyphenol Lignans

    Artichoke is fairly difficult to prepare for me so I usually take this important Polyphenol as an extract supplement.

Grape Seed Extract, Olive Leaf Extract, Pomegranate, Cocoa, Flax and green tea extract have been my prime antioxidant stand by foods and supplements for over 40 years. I have long eaten nuts and artichokes for their health benefits.  How nice to now see the wisdom of this eating. Now I also eat a lot of lentils.

      

Spices Are Strong Sources of Polyphenols as a CLASS

      

Spices comprise most of the top high phenolic herbs and foods.

Cloves and cinnamon emerged as the leading spices in phenolic content among the extracts tested. Phenols are plant compounds which have an antioxidant property. The total phenolic content of cloves was found to be 30 percent of its dry weight, which is significantly higher than blueberries, a food that is known for its antioxidant and phenolic content; cocoa is another high phenolic spice.

The team discovered a strong correlation between the extracts’ phenol content and their ability to block AGE formation. Other extracts which significantly inhibited glycation were Jamaican allspice and apple pie spice, which is a blend of allspice, cinnamon and nutmeg. The remaining herbs and spices, including oregano, Cumin, sage, rosemary, and turmeric, also showed an ability to inhibit glycation, but at lesser dilutions. By extension any high ORAC (See ORAC Protocol) food or spice should offer good glycation protection.

However you do it get a LOT of high polyphenolic foods and supplements.

    

Flavonoids Protocol

"Flavonoids are polyphenolic compounds that are ubiquitous in nature and are categorized, according to chemical structure, into flavonols, flavones, flavanones, isoflavones, catechins, anthocyanidins and chalcones. Over 4,000 flavonoids have been identified, many of which occur in fruits, vegetables and beverages (tea, coffee, beer, wine and fruit drinks). The flavonoids have aroused considerable interest recently because of their potential beneficial effects on human health-they have been reported to have antiviral, anti-allergic, antiplatelet, anti-inflammatory, antitumor and antioxidant activities."   Antioxidant Activities of Flavonoids

http://www.nature.com/scientificamericanmind/journal/v24/n1/images/scientificamericanmind0313-16-I2.jpg

Flavonoids: Chemical Compounds Derived from Plants

    

"The unique nutrient richness of every whole, natural food can be showcased in a variety of ways. But there is no better way to highlight the unique nutrient richness of foods than to focus on their flavonoid content! Flavonoids are a quite remarkable group of phytonutrients that fall into the chemical category of polyphenols. They're perhaps most famous for their rich diversity of color-providing pigments (including the deep blues of blueberries and rich reds of raspberries)."   WHF Flavonoids

“Dietary anthocyanins have a significant potency for anti-obesity.” Tsuda

“Powerful antioxidants flavonoids are linked with health benefits that include protection from cancer, cardiovascular disease, dementia, diabetes and stroke.”    Cao et al, American J of clinical Nutrition 1998 Nov

"The second study followed 41 medicated diabetic patients. They divided the patients into two groups. They gave the first group flavanol-rich cocoa (321 mg flavanols). They gave the second (control) group a nutrient-matched control (25 mg of flavanols). They gave each solution three times a day for 30 days. Those in the flavanols-rich cocoa supplemented group had a wonderful 30% increase in FMD, a key circulation marker, compared to the control group." Doctor Robert Jay Rowen

"In an article published online on July 10, 2009 in the journal Diabetes, researchers in Ontario, Canada report that naringenin, a flavonoid present in citrus fruit, prevents weight gain and components of metabolic syndrome, a precursor to diabetes, in a rodent model. The research team discovered that naringenin genetically reprograms the liver to burn extra fat as opposed to storing it. These studies show naringenin, through its insulin-like properties, corrects many of the metabolic disturbances linked to insulin resistance and represents a promising therapeutic approach for metabolic syndrome,"    Life Extension

"Researchers found that a high intake of flavonols from beans, onions, apples, and tea can significantly lower your risk of colon cancer. Patients in the highest flavonols quartile  reduced their advanced adenoma recurrence by 76% compared to the lowest quartile.”   Doctor Robert Rowen MD

"Flavonoids are remarkable natural compounds that have a wide range of healing effects on your body. In the test tube flavonoids have up to five times the antioxidant power of vitamin C. They hunt down and absorb free radicals before they cause aging and disease."  Doctor Victor Marchione MD

"The peel of lemons, limes, oranges and grapefruit contain the newly discovered nutrient flavones. Flavones have many  powerful health benefits such as lowering cholesterol, anti-cancer, anti-estrogenic, anti-CVD, anti-neurodegeneration, modulated cellular signaling and others."   Doctor Victor Marchione MD, Note find a way to eat these POWERFUL peels at least all the white and SOME of the outer rind. You can do it; it is a little work. I rarely waste this powerful food; I have gotten used to its taste

"A rich source of flavonoids cranberries are also arousing interest for their potential to reduce the formation of arterial plaque."   Life Extension

“Those fed the mulberry-supplemented chow had an amazing 40% reduction in their atherosclerotic lesions in their aortas. Mulberry extract also slowed oxidation of lipids in the test tube, a possible mechanism of action. The authors concluded that mulberry leaf might help prevent atherosclerosis. This report caused me to look deeper into mulberry. Its leaves contain rather significant amounts of flavonoids. These are in the quercetin family. Mulberry also has attenuated diabetes in animals.”   Doctor Robert Rowen MD

"Cranberries contain two powerful flavonoids quercetin and myricetin and the dark versions also contain kaempferol. Each of these compounds has been shown to prevent genetic changes that can lead to cancer."   Prevention  

"A growing body of evidence indicates that flavonoids are an integral component of any cancer-preventive strategy.3 Two of these flavonoids, apigenin and luteolin, found in celery are distinguished for their ability to protect against various types of cancer.4"   Time to Celebrate Celery

"Cocoa, the spice, is one of the richest sources of flavanols, plant compounds that help protect the heart in a variety of ways. Study after study shows that cocoa flavanols can disarm cell damaging free radicals. preserve cell membranes. protect DNA., prevent the formation of artery clogging plaque, improve blood flow to the heart. lower high blood pressure and prevent blood clots that can cause a heart attack or stroke."   Healing Spices   Note WOW

“The rule of thumb with fruits and vegetables is that the deeper and richer the color, the more nutritious the content tends to be. The purple potato is no exception to this rule. It is rich in the antioxidant that is characteristic of deeply colored blue or purple produce called anthocyanin. This compound is from the powerful flavonoid family of antioxidants and is found in other nutritional powerhouse foods such as blueberries and pomegranates. It is most well-known for its immunity boosting and cancer fighting properties."   Purple potatoes pack serious antioxidants compared to their white-fleshed counterparts

All flavonoids, often called bioflavonoids, are polyphenols. The flavonoid class of polyphenols consist of stilbenes, lignans, anthocyanins. and others. Some of the more common Flavonoids are Bilberry, Quercetin, Genistein, Rutin, Hesperidin, and Epigallocatechin.  Note flax seeds have 100s of times more lignans than the next highest source. EAT FLAX.

All these powerful plant compounds can have a very positive effect on your overall health. IMO it will pay you to pack many of these salubrious plant compounds into your diet.

     

Flavonoids a Vitamin C Complex Components Component

“Most sources equate vitamin C with ascorbic acid, as though they were the same thing. They're not. Ascorbic acid is an isolate, a fraction, a distillate of naturally occurring vitamin C. In addition to ascorbic acid, vitamin C must include rutin, bioflavonoids, Factor K, Factor J, Factor P, Tyrosinase, Ascorbinogen, and other components”  Doctor Tim O'Shea,   Note ascorbate can provide you a powerful tool but you must realize you also need ALL the other components of the Vitamin C Complex Components. A good way to do this is to eat a COMPLETE Orange along with all those grams of ascorbate. I take a LOT, Rutin, Bioflavonoids, Quercetin, L-Tyrosine, hesperidin, bromelain and WHOLE Lemon, of the Vitamin C Complex Components DAILY as my Vitamin C supplement.

"Flavonoids are remarkable natural compounds that have a wide range of healing effects on your body. In the test tube flavonoids have up to five times the antioxidant power of vitamin C. They hunt down and absorb free radicals before they cause aging and disease."  Doctor Victor Marchione MD

"One of the best ways to maintain the health of your capillaries is with a bioflavonoid found naturally in fruits and vegetables called rutin. Rutin has the capacity to regenerate vitamin C after it neutralizes a free radical, thus helping to restore its antioxidant potential.14 Because vitamin C plays a critical role in the manufacture of collagen, an important component of capillary walls as well as the sustaining framework of the epidermis, this could have a dramatic impact on the health of your skin."    How Bioflavonoids Create Youthful Skin Tone   Note Rutin a component of the Vitamin C Complex Components helps to recycle the oxidized vitamin C making it ready to absorb another free radical if required

"In this antioxidant context, it is also worth pointing out the potentially unique relationship between flavonoids and vitamin C. Recent studies have shown the ability of flavonoids to alter transport of vitamin C, as well as to alter function of an enzyme called ascorbate oxidase, which converts vitamin C into a non-vitamin form (monodehydroascorbate). While we do not yet know the full meaning of these relationships, it is clear that the transport and cycling of vitamin C is flavonoid related. This association makes sense to us, since so many foods high in vitamin C (such as our top five WHFoods for vitamin C are papaya, bell peppers, broccoli, Brussels sprouts, and strawberries) are also high in flavonoids."    WHF Flavonoids

Several flavonoids, including, Rutin, Hesperidin, Quercetin are components of the Vitamin C Complex Components. Make sure you are getting ALL of the Vitamin C Complex Components by eating a LOT of flavonoids.

            

Flavonoids a KEY to Good Health

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"Flavonoids are polyphenolic compounds that are ubiquitous in nature and are categorized, according to chemical structure, into flavonols, flavones, flavanones, isoflavones, catechins, anthocyanidins and chalcones. Over 4,000 flavonoids have been identified, many of which occur in fruits, vegetables and beverages (tea, coffee, beer, wine and fruit drinks). The flavonoids have aroused considerable interest recently because of their potential beneficial effects on human health-they have been reported to have antiviral, anti-allergic, antiplatelet, anti-inflammatory, antitumor and antioxidant activities."   Antioxidant Activities of Flavonoids

"Polyphenols also known as Polyhydroxyphenols, are a structural class of mainly natural, organic chemicals characterized by the presence of large multiples of phenol structural units. They may be broadly classified as phenolic acids, flavonoids, stilbenes, and lignans."   "Polyphenols: food sources and bioavailability". Am J Clin Nutr; 79: 727– , Note here we see flavonoids constitute most of the food based polyphenols

Flavonoids often called Bioflavonoids are anti-oxidant (See Antioxidant Protocol) nutrients that are part of the Vitamin C Complex Components that cannot be synthesized by your body. Flavonoids slow the release of vitamin C from your intestine thus increasing vitamin C’s salubrious effect. Research has clearly documented the synergistic relationship between Flavonoids and vitamin C.

Oligomeric Procyanidins (OPCs), also called Proanthocyanidins, are a class of nutrients belonging to the flavonoid family.  

Some of the more common Flavonoids are Bilberry, Quercetin, Genistein, Rutin, Hesperidin, and Epigallocatechin. 

Flavonoids are known for their ability to chelate metals from your body. Flavonoids maintain collagen. They are found in the skin, white and flesh of over 4000 fruit and vegetables and beverages (tea, coffee, beer, wine and fruit drinks). The flavonoids have antiviral, anti-allergic, anti-platelet, anti-inflammatory, anti-tumor and antioxidant activities.

The more vibrant the color the more flavonoid contained. Try to eat a wide variety of brightly colored fruits and vegetables; the more brightly colored and varied fruits and vegies you eat the better your flavonoid intake. Flavonoid consumption has been shown to protect against disease by nourishing the integrity and strength of capillaries and cells. Berries are a proven great source of flavonoids and a lot more.

     

Flavonoids Increase Life Span

"Dr. Cimen Karasu is the head of the Department of Medical Informatics in the Faculty of Medicine at Gazi University in Turkey. She has authored more than a hundred papers appearing in peer-reviewed journals. Dr. Karasu's talk was largely a review of the damaging effects of free radicals and advanced glycation end-products (AGEs). She noted that flavonoids have been shown to increase the life span of nematode worms.21 She reviewed the benefits of a number of natural polyphenols, including quercetin and pomegranate extracts.22,23 She is starting a company in Turkey which will market a formulation based on olive leaf polyphenols.24,25 "

Folks please do not ignore the copious and well documented evidence and GET a LOT of flavonoids in your life.    

      

Flavonoids Are Very Important for Your Veins

"Rutin helps fight spider veins and varicose veins by maintaining healthy blood circulation. It also decreases capillary permeability and makes the blood thinner,6 thereby improving microcirculation so the skin cells receive more oxygen and nutrients."   Life Extension

"Three of the better-known bioflavonoids, quercetin, hesperidin, and rutin, have intriguing research indicating their abilities to prevent and reverse wrinkles, reduce the appearance of age spots, and fight spider veins.3-6. As potent as these plant metabolites are on their own, they exhibit an even greater effect when they're  used  together, as studies have shown they work synergistically by harmonizing with each other 20,21."   How Bioflavonoids Create Youthful Skin Tone

"Harvard researchers have found that a flavonoid compound in apples called rutin (it’s also found in onions, buckwheat, citrus fruits, and tea) has powerful properties that prevents blood clots in heart vessels. Rutin could prevent both the arterial clots that cause heart attacks and strokes and the venous clots that cause deep-vein thrombosis and pulmonary embolism."

"Chronic Venous Insufficiency A condition in which the veins do not efficiently return blood from the legs to the heart, chronic venous insufficiency is linked to problems like varicose veins, ankle swelling, and nighttime leg cramping. Supplements containing a combination of hesperidin, extract of the herb butcher's broom, and ascorbic acid (a form of vitamin C) may help treat chronic venous insufficiency, according to a 2007 study published in International Angiology."   Hesperidin and Chronic Venous Insufficiency

All the flavonoids are very protective and restorative for your veins. If you are having any sort of problems with your veins please do not pass up any chance you have to EAT a good chunk, flesh AND skin of any citrus fruit you get  your hands on. Yeah eating a lemon skin may not be pleasant BUT IMO it is far better than spending the rest of your life in a chair or worse. Just take a single bite to start. Be careful to protect your teeth from the acid by washing them with water immediately after.

   

Flavonoid Benefits

“Flavonoids have demonstrated antioxidant, antimutigenic and antiproliferative properties in laboratory studies. The findings from this large network of Italian case-control studies have provided support for an apparent protective role of flavanones on upper aerodigestive tract cancers; flavonols, anthocyanidins, and proanthocyanidins on colorectal cancer; flavonols and flavones on breast cancer; isoflavones on ovarian cancer; and flavonols on renal cancer,"   Doctor Carlo La Vecchia

"Bioflavonoids have the ability to neutralize reactive oxygen species by donating one of their electrons, thus stabilizing the molecule and breaking the oxidative chain.2 This can result in visible signs of healthy, more vibrant skin."    Life Extension

"A recent article in the journal Neurology examined whether higher intakes of total flavonoids and their subclasses (flavanones, anthocyanins, flavan-3-ols,  flavanols, flavones and polymers) were associated with an lower risk of Parkinson's disease (PD). Men after adjusting for multiple cofounders in the highest quintile of total flavonoids has a 40% lower PD risk than those in the lowest quintile."   Life Extension

"Three of the better-known bioflavonoids, quercetin, hesperidin, and rutin, have solid research behind them proving their power to prevent and reverse wrinkles, reduce the appearance of age spots, and even fight spider veins and varicose veins."   Life Extension

Flavonoids vastly increase the bioavailability of Vitamin C

    

  • Flavonoids vastly increase the bioavailability of Vitamin C

  • Antioxidants

  • Anti-Aging

  • Anti-Allergen

  • Anti-Viral

  • Anti-Arterial Plaque

  • Anti-Cancer

  • Anti-Estrogenic

  • Anti-Excess Clotting

  • Anti-CVD

  • Protective and Restorative of Your Veins

  • Anti-LDL oxidation

  • Anti-Neurodegeneration

  • Anti-Parkinson's Disease

  • Anti-Tumor

  • Anti-Viral

  • Both water and fat soluble

  • Chelation of metals and more

  • Modulates Cell Signaling

  • Pro-Collagen

  • Pro-Glucose Mechanism

  • Pro-Immune

  • Pro-DNA

  • Pro-Endothiailal

  • Pro-Liver

  • Pro-Skin Health

  • Vitamin C Component

  • Flavonoids vastly increase the bioavailability of Vitamin C

   

http://www.nature.com/scientificamericanmind/journal/v24/n1/images/scientificamericanmind0313-16-I2.jpg

Some of the more common Flavonoids are Bilberry, Quercetin, Genistein, Rutin, Hesperidin, wine, tea, cocoa and Epigallocatechin. These are found in vegetables and fruits, herbs, citrus fruits, blue, red and purple fruits.

A lot of research is showing that eating flavonoids DAILY can significantly improve many aspects of your health. IMO you want to include these valuable components into your DAILY diet. IMO these flavonoids are a KEY to good health. You will be assured of getting concentrated flavonoids daily if you include them with your vitamin C (See Vitamin C Protocol) 

Unfortunately, food processing (See Processed Food Protocol) removes most of the Flavonoids. Therefore, as we have consistently maintained, eating unprocessed foods every day is the doorway to good health.

   

Eat the WHOLE Citrus Fruit Food

Most of the goodies like the flavonoid hesperidin, in citrus are in the skin and white rind (See Citrus Peel Extract Protocol). When I eat citrus often I wash it completely, dry it, cut off the imperfections on the skin and cut a slice or the WHOLE citrus into very SMALL pieces and put it in a shake or put it in my tea. After drinking the tea; EAT everything in the cup.

        

Anthocyanins Are Flavonoids Are Polyphenols

http://www.nature.com/scientificamericanmind/journal/v24/n1/images/scientificamericanmind0313-16-I2.jpg

"The class of polyphenols known as anthocyanins composed of deep red, blue and purple pigments possess powerful antioxidant properties. Fruits and vegetables of these colors blueberries, cranberries, pomegranates, black currents beets and acai are especially rich in anthocyanins. They are highly bioavailable and can significantly increase levels of other beneficial polyphenols in the blood. "  Life Extension

"Extensive research confirms that the most powerful antioxidant berries are those that contain a class of polyphenols known as anthocyanins. These nutrients create the deep red, blue, and purple pigments found in plants such as blueberries, elderberries, blackberries, and açaí. Berry anthocyanins strongly combat oxidative stress, a causative factor in the pathogenesis of many major diseases such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), cancer, and allergic disorders."   Uncovering the Broad-Spectrum Protection of Anthocyanins

"Recent evidence indicates that anthocyanin-rich foods exert their effects through multiple mechanisms that go far beyond berries’ well-known antioxidant activity. These underlying pathways have been shown to:"   Uncovering the Broad-Spectrum Protection of Anthocyanins

"Polyphenols are chemicals that, by their intrinsic structure, diminish the effects of free radicals on surrounding tissues. The anthocyanin class of polyphenols is especially effective in blunting oxidative damage."   Life Extension

"One of nature’s most potent classes of flavonoids is anthocyanins. These powerhouse nutrients are responsible for the deep colors in some berries, fruits, and vegetables. Naturally, like other anthocyanin-rich foods, tart cherries deliver substantial antioxidant and anti-inflammatory activity. But tart cherries are superior because they provide high levels of some novel anthocyanins that are absent from a number of other anthocyanin-rich foods, such as blueberries or bilberries! Also, the unique composition of tart cherries goes far beyond anthocyanins. In fact, tart cherries were shown to contain much higher amounts of total phenolics than even their nutritious cousins, sweet cherries. Aside from a greater abundance of anthocyanins, tart cherries also deliver a cast of supporting compounds."   Anti-Inflammatory Properties of Tart Cherry

"A large proportion of deaths in the modern world are caused by type II diabetes, cardiovascular disease, and neurodegenerative disorders (such as Alzheimer’s and Parkinson’s). Studies have linked the rising incidence of these conditions in large part to our access to excess calories, which disrupts natural protective processes and causes us to gain weight, increases chronic levels of inflammation, and contributes to cellular aging.5-10 Three new studies on anthocyanins are of particular interest to those afflicted by these degenerative illnesses."   Berries Reduce Disease Risk

"Researchers continue to discover a wide variety of health benefits provided by berries. Berries contain bioactive natural pigments called anthocyanins. Used for thousands of years in traditional medicine,1 these water-soluble plant pigments are what give plants their wide range of colors, from blue and purple, to red and orange. Anthocyanins have a broad spectrum of biological effects, exerting antimicrobial, cell-protective, antitumor, lipid-lowering, and neuroprotective properties—all of which have implications for disease prevention and promotion of good health.1,3,4 Despite these impressive benefits, the therapeutic opportunities for using anthocyanins have been largely overlooked. Three new studies provide further insight on the potential of anthocyanins to help reduce risks of type II diabetes, cardiovascular disease, and neurodegeneration."   Berries Reduce Disease Risk

"The researchers believe that the ability of anthocyanins to reduce cardiovascular risk might arise from the combination of reduced blood pressure, improved endothelial (blood vessel lining) function, and increased insulin sensitivity."   Berries Reduce Disease Risk

"Recent studies demonstrate that high consumption of anthocyanins is associated with reduced risks of type II diabetes and cardiovascular disease. A new animal study shows that anthocyanin supplementation can protect against brain changes associated with Alzheimer’s and Parkinson’s diseases."    Berries Reduce Disease Risk

"Anthocyanins have tremendous potential to reduce misery and disease. The primary dietary sources of anthocyanins are dark fruits, especially berries. Even if Americans increase their consumption of cherries, strawberries, blackberries, blueberries, and others, few will be able to do it consistently enough to substantially affect healthy aging. Overconsumption of any fruit, even including berries, can overload the body with fructose (fruit sugar). Fortunately, anthocyanin extracts can achieve similar benefits to berries themselves. Interestingly, because these highly concentrated anthocyanin extracts are inherently stable; they cost less when taken as supplements compared to buying fresh fruits that spoil rapidly."   Best Sources for Anthocyanins

    

Anthocyanins are flavonoids and are plant based polyphenols called anthocyanins. recognized by their very deep, rich black, blue and purple colors these fruits and vegetables are a very rich source of antioxidant protection and more.

Life Extension recommends that aging seniors should get FIVE servings of the dark blue black anthocyanins a DAY. This is not easy to but IMO is a most worthwhile goal. You are probably not going to get all these anthocyanins without SUPPLEMENTING. Do it!

  

Anthocyanin Benefits

  • Inhibit Cancer Growth

  • Reduce CVD Risk

  • Reduces Alzheimer's Risk

  • Reduces Parkinson's Risk

  • Reduces Inflammation

  • Promotes Endothelial Function

  • Helps HBP

  • Enhance Glucose Tolerance

  • Improve Eye Health and night vision

  • Limit DNA Oxidative Damage

  • Aids Graceful Healthy Aging

  • Fight Metabolic Syndrome

  • Improves insulin sensitivity

  • Fights Obesity

          

Anthocyanin Rich Fruits

"Also known as chokeberries, aronia berries have been found to yield very high ORAC values. Aronia has been shown to decrease lipid peroxidation, as well as oxidative stress. In vitro research found an anti-clotting effect. Drinking aronia berry juice reduced exercise-induced oxidative damage to red blood cells."   Uncovering the Broad-Spectrum Protection of Anthocyanins

Bilberry  

"Bilberry, a relative of the blueberry, promotes frontline prevention against cardiovascular disease by significantly inhibiting angiotensin-converting enzyme (ACE), which contributes to hypertension by promoting narrowing of the arteries (vasoconstriction). Bilberries improve insulin sensitivity, which may help ward off diabetes. They also enhance short-term memory in animal models, suggesting the potential to help prevent Alzheimer’s disease."   Uncovering the Broad-Spectrum Protection of Anthocyanins

"Studies demonstrate that blackcurrants relax the aorta by enhancing the synthesis of nitric oxide, improving the functioning of blood vessels, and reducing susceptibility of low-density lipoprotein (LDL) to oxidative stress, resulting in cardioprotective benefits. Blackcurrant anthocyanins improve blood flow in the human forearm and have been shown to reduce muscle fatigue and stiffness."   Uncovering the Broad-Spectrum Protection of Anthocyanins

"Both sweet and tart varieties of cherry have exhibited potent cardiovascular and antidiabetic effects. Traditionally associated with the soothing of arthritis and gout, cherries have been found to block inflammatory pathways associated with these diseases;93-95 and a 2012 study found cherry intake reduced gout attacks by 35%.96 These berries and their extract also inhibit the inflammatory processes involved in heart disease.94,95,97"   Uncovering the Broad-Spectrum Protection of Anthocyanins

"But cranberries and cranberry juice are probably best known for their ability to help prevent urinary tract infections,110,111 and are believed to work by inhibiting the adherence of E. coli to the urethra and bladder wall, making it easier for the body to flush them out.112,113 Similarly, they may protect against gastric ulcers by preventing Helicobacter pylori, the bacterium implicated in this condition, from adhering to the stomach lining.114,115"   Uncovering the Broad-Spectrum Protection of Anthocyanins

"Elderberry also delivers cardioprotective benefits by reducing lipid peroxides, neutralizing lipid peroxyl radicals, inhibiting LDL oxidation, and significantly protecting endothelial cells against oxidative stress. A remarkable recent study found elderberry extract reverses hyperlipidemia (high cholesterol) and lipid peroxidation."   Uncovering the Broad-Spectrum Protection of Anthocyanins

"A diet high in strawberries was found effective in protecting animals from age-related deficits in learning and memory. Researchers confirmed in 2012 that, although eating more berries may reduce cognitive decline in elderly humans, “flavonoid-rich blueberries and strawberries offer [the] most benefit.”   Uncovering the Broad-Spectrum Protection of Anthocyanins

 

  • Acai

  • Aronia

  • Bilberry

  • Blackberry

  • Blackcurrant

  • Blueberry

  • Blue Corn

  • cherry

  • Cranberry

  • Elderberry

  • Grape

  • Pomegranate

  • Prune

  • Raspberry

  • Strawberry

    

   

More on Flavonoids:

http://www.acu-cell.com/bio.html

http://www.raysahelian.com/flavonoids.html

http://lpi.oregonstate.edu/f-w00/flavonoid.html

 

 

This File was last updated on 16 August 2020 07:53 AM

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